Perkütan Endoskopik Gastrostomi (PEG)

Yazarlar

Deniz Öçal

Özet

Perkütan Endoskopik Gastrostomi (PEG), oral beslenmesi yetersiz olan ve 4-6 hafta süreyle enteral beslenme desteğine ihtiyaç duyan, fonksiyonel gastrointestinal sisteme sahip hastalarda uluslararası kılavuzlar tarafından öncelikli olarak önerilen, düşük maliyetli ve minimal invaziv bir yöntemdir. İlk kez 1980 yılında uygulanan bu endoskopik işlem, özellikle serebrovasküler hastalıklar, demans, Parkinson gibi nörolojik rahatsızlıklar ile baş-boyun kanserleri ve yoğun bakım hastalarında malnütrisyon gelişimini önlemek ve hastanın yaşam kalitesini artırmak amacıyla yaygın şekilde tercih edilmektedir. Ciddi pıhtılaşma bozuklukları, hemodinamik instabilite, peritonit ve sepsis gibi durumlarda kesinlikle uygulanmaması gereken bu prosedür, genel olarak güvenli kabul edilse de belirli majör ve minör komplikasyon riskleri barındırmaktadır. Klinik süreçte masif kanamalar, ölümcül seyredebilen aspirasyon pnömonisi, bağırsak perforasyonu gibi iç organ yaralanmaları, nekrotizan fasiit, tümör ekilimi ve gömülü tampon sendromu ciddi majör komplikasyonlar arasında yer alır. Bununla birlikte, stoma sızıntısı, lokal yara enfeksiyonları, tüpün tıkanması veya yerinden çıkması ile granülom oluşumu gibi minör sorunlar da sıklıkla gözlenmektedir. Başarılı bir PEG uygulaması için işlem öncesinde hastanın en az 8 saat aç kalması, profilaktik antibiyotik alması ve pıhtılaşma değerlerinin normal sınırlarda olması gerekir. En sık kullanılan "çekme" tekniğinin yanı sıra, işlem sonrasında tüpün düzenli yıkanması, stoma bakımı ve beslenme esnasında hastanın 30-45 derece açıyla oturtulması kritik önem taşır.

Percutaneous Endoscopic Gastrostomy (PEG) is a highly effective, cost-efficient, and minimally invasive enteral feeding pathway recommended by international guidelines for patients with a functional gastrointestinal tract who require nutritional support for more than four to six weeks. Introduced in 1980, this endoscopic procedure is widely indicated for individuals suffering from neurological dysphagia, such as stroke, dementia, and Parkinson's disease, as well as head and neck malignancies, head traumas, and critical illnesses in intensive care units to systematically prevent severe malnutrition and optimize overall quality of life. Although PEG is considered a reliable intervention, it is strictly contraindicated in cases of severe uncorrectable coagulopathy, hemodynamic instability, peritonitis, and active sepsis. The procedure carries inherent risks of major complications, including massive gastrointestinal bleeding, life-threatening aspiration pneumonia, accidental visceral organ perforation, necrotizing fasciitis, tumor seeding along the tract, and buried bumper syndrome. Additionally, minor complications such as localized wound infections, peristomal leakage, tube displacement, occlusion, and granulation tissue formation are frequently encountered in clinical practice. Pre-procedural preparation demands an explicit eight-hour fasting window, prophylactic antibiotic treatment, and coagulation screening. While the "pull" method remains the global standard for insertion, meticulously executed post-procedural care—including scheduled tube flushing, stoma evaluation, and maintaining a 30-to-45-degree patient elevation during feeding—is critical to preventing adverse outcomes.

Referanslar

Bischoff SC, Austin P, Boeykens K, et al. . ESPEN guideline on home enteral nutrition. Clin Nutr 2020;39:5–22. 10.1016/j.clnu.2019.04.022.

Gauderer MW, Ponsky JL, Izant RJ Jr .Gastrostomy without laparotomy: a percutaneous endoscopic technique. J Pediatr Surg 1980;15:872-5.

Alverdy J, Chi HS, Sheldon GF. The effect of parenteral nutrition on gastrointestinal immunity. The importance of enteral stimulation. Ann Surg. 1985;202:681–684.

Deitch EA, Ma WJ, Ma L, Berg RD, Specian RD. Protein malnutrition predisposes to inflammatory-induced gut-origin septic states. Ann Surg. 1990;211:560–567.

Deitch EA, Winterton J, Li M, Berg R. The gut as a portal of entry for bacteremia. Role of protein malnutrition. Ann Surg. 1987;205:681–692.

Lord LM. Enteral access devices: types, function, care, and challenges. Nutr Clin Pract 2018;33:16–38. 10.1002/ncp.10019.

Mekhail TM, Adelstein DJ, Rybicki LA, Larto MA, Saxton JP, Lavertu P. Enteral nutrition during the treatment of head and neck carcinoma: is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube? Cancer. 2001;91:1785–1790.

Park RH, Allison MC, Lang J, Spence E, Morris AJ, Danesh BJ, Russell RI, Mills PR. Randomised comparison of percutaneous endoscopic gastrostomy and nasogastric tube feeding in patients with persisting neurological dysphagia. BMJ. 1992;304:1406–1409.

Bannerman E, Pendlebury J, Phillips F, Ghosh S. A cross-sectional and longitudinal study of health-related quality of life after percutaneous gastrostomy. Eur J Gastroenterol Hepatol. 2000;12:1101–1109.

Given MF, Hanson JJ, Lee MJ. Interventional radiology techniques for provision of enteral feeding. Cardiovasc Intervent Radiol 2005; 28:692.

Foutch PG, Talbert GA, Waring JP, Sanowski RA. Percutaneous endoscopic gastrostomy in patients with prior abdominal surgery: virtues of the safe tract. Am J Gastroenterol. 1988;83:147–150.

Bender JS. Percutaneous endoscopic gastrostomy placement in the morbidly obese. Gastrointest Endosc 1992; 38:97.

Karhadkar AS, Naini P, Dutta SK. PEG-tube placement in a patient with extreme obesity: overcoming the technical challenges. Gastrointest Endosc 2007; 65:731.

Senadhi V, Chaudhary J, Dutta S. Percutaneous endoscopic gastrostomy placement during pregnancy in the critical care setting. Endoscopy. 2010;42 Suppl 2:E358–E359. 63.

Irving PM, Howell RJ, Shidrawi RG. Percutaneous endoscopic gastrostomy with a jejunal port for severe hyperemesis gravidarum. Eur J Gastroenterol Hepatol. 2004;16:937–939.

Kynci JA, Chodash HB, Tsang TK. PEG in a patient with ascites and varices. Gastrointest Endosc. 1995;42:100–101.

Horiuchi A, Nakayama Y, Tanaka N. Transgastric Diversion of Transnasal Long Tube Placement Using a Percutaneous Endoscopic Gastrostomy Site in a Patient with Bowel Obstruction and Massive Ascites due to Ovarian Carcinoma. Case Rep Gastroenterol. 2008;2:326–329.

Baltz JG, Argo CK, Al-Osaimi AM, Northup PG. Mortality after percutaneous endoscopic gastrostomy in patients with cirrhosis: a case series. Gastrointest Endosc. 2010;72:1072–1075.

Wilson L, Oliva-Hemker M. Percutaneous endoscopic gastrostomy in small medically complex infants. Endoscopy. 2001;33:433–436.

Zopf Y, Maiss J, Konturek P, Rabe C, Hahn EG, Schwab D. Predictive factors of mortality after PEG insertion: guidance for clinical practice. JPEN J Parenter Enteral Nutr. 2011;35:50–55.

Lee C, Im JP, Kim JW, et al. . Risk factors for complications and mortality of percutaneous endoscopic gastrostomy: a multicenter, retrospective study. Surg Endosc 2013;27:3806–15.

Vujasinovic M, Ingre C, Baldaque Silva F, et al. . Complications and outcome of percutaneous endoscopic gastrostomy in a high-volume centre. Scand J Gastroenterol 2019;54:513–8. 10.1080/00365521.2019.1594354.

Schurink CA, Tuynman H, Scholten P, Arjaans W, Klinkenberg-Knol EC, Meuwissen SG, Kuipers EJ. Percutaneous endoscopic gastrostomy: complications and suggestions to avoid them. Eur J Gastroenterol Hepatol. 2001;13:819–823.

Lucendo AJ, Sánchez-Casanueva T, Redondo O, et al. . Risk of bleeding in patients undergoing percutaneous endoscopic gastrotrostomy (PEG) tube insertion under antiplatelet therapy: a systematic review with a meta-analysis. Rev Esp Enferm Dig 2015;107:128–36.

Veitch AM, Vanbiervliet G, Gershlick AH, et al. . Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of gastroenterology (Bsg) and European Society of gastrointestinal endoscopy (ESGE) guidelines. Endoscopy 2016;48:385–402. 10.1055/s-0042-102652.

Marco J, Barba R, Lázaro M, Matía P, Plaza S, Canora J, Zapatero A. Bronchopulmonary complications associated to enteral nutrition devices in patients admitted to internal medicine departments. Rev Clin Esp. 2013;213:223–228.

Finucane TE, Bynum JP. Use of tube feeding to prevent aspiration pneumonia. Lancet. 1996;348:1421–1424.

Gkolfakis P, Arvanitakis M, Despott EJ, et al. . Endoscopic management of enteral tubes in adult patients - Part 2: Peri- and post-procedural management. European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2021;53:178–95. 10.1055/a-1331-8080.

Berger SA, Zarling EJ. Colocutaneous fistula following migration of PEG tube. Gastrointest Endosc 1991; 37:86.

Toussaint E, Van Gossum A, Ballarin A, et al. . Enteral access in adults. Clin Nutr 2015;34:350–8. 10.1016/j.clnu.2014.10.009.

MacLean AA, Miller G, Bamboat ZM, Hiotis K. Abdominal wall necrotizing fasciitis from dislodged percutaneous endoscopic gastrostomy tubes: a case series. Am Surg. 2004;70:827–831.

Roje Z, Roje Z, Matić D, et al. . Necrotizing fasciitis: literature review of contemporary strategies for diagnosing and management with three case reports: torso, abdominal wall, upper and lower limbs. World J Emerg Surg 2011;6:46. 10.1186/1749-7922-6-46.

Roveron G, Antonini M, Barbierato M, et al. . Clinical practice guidelines for the nursing management of percutaneous endoscopic gastrostomy and jejunostomy (PEG/PEJ) in adult patients: an executive summary. J Wound Ostomy Continence Nurs 2018;45:326–34.

Wescott B, Seegmiller S, Mohamed Elfadil O, Mohamed O, et al. . Seeding of gastrostomy tube site in patient with squamous cell carcinoma of the tongue: a case report. Nutr Clin Pract 2020;0:1–6. 10.1002/ncp.10606.

Rahnemai-Azar AA, Rahnemaiazar AA, Naghshizadian R, et al. . Percutaneous endoscopic gastrostomy: indications, technique, complications and management. World J Gastroenterol 2014;20:7739–51. 10.3748/wjg.v20.i24.7739.

Fung E, Strosberg DS, Jones EL, et al. . Incidence of abdominal wall metastases following percutaneous endoscopic gastrostomy placement in patients with head and neck cancer. Surg Endosc 2017;31:3623–7. 10.1007/s00464-016-5394-8.

Geer W, Jeanmonod R. Early presentation of buried bumper syndrome. West J Emerg Med. 2013;14:421–423.

Cyrany J, Rejchrt S, Kopacova M, et al. . Buried bumper syndrome: a complication of percutaneous endoscopic gastrostomy. World J Gastroenterol 2016;22:618–27.

Afifi I, Zarour A, Al-Hassani A, et al. . The challenging buried Bumper syndrome after percutaneous endoscopic gastrostomy. Case Rep Gastroenterol 2016;10:224–32. 10.1159/000446018

Kurt B, Ivo D. Prevention and management of major complications in percutaneous endoscopic gastrostomy. BMJ Open Gastroenterol. 2021; 8(1): e000628. 2021 May 4. doi: 10.1136/bmjgast-2021-000628.

Vanis N, Saray A, Gornjakovic S, Mesihovic R. Percutaneous endoscopic gastrostomy (PEG): retrospective analysis of a 7-year clinical experience. Acta Inform Med. 2012;20:235–237.

Jafri NS, Mahid SS, Minor KS, et al. Meta-analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy. Aliment Pharmacol Ther 2007; 25:647.

Chaudhary KA, Smith OJ, Cuddy PG, Clarkston WK. PEG site infections: the emergence of methicillin resistant Staphylococcus aureus as a major pathogen. Am J Gastroenterol 2002; 97:1713.

Alkartha A, Kawji AS, Alder DG. First reported case of Candida galbrata perihepatic abscess as a complication of percutneous endoscopic gastrostomy tube placement. J Clin Gastro 2007; 41:335.

Horiuchi A, Nakayama Y, Kajiyama M, et al. Nasopharyngeal decolonization of methicillin-resistant Staphylococcus aureus can reduce PEG peristomal wound infection. Am J Gastroenterol 2006; 101:274.

Lagergren J, Mattsson F, Lagergren P. Clinical implementation of a new antibiotic prophylaxis regimen for percutaneous endoscopic gastrostomy. BMJ Open. 2013;3.

Lynch CR, Fang , J Prevention and management of complications of percutaneous endoscopic gastrostomy (PEG) tubes. Prac Gastroenterol. 2004;28:66–77.

Rosenberger LH, Newhook T, Schirmer B, Sawyer RG. Late accidental dislodgement of a percutaneous endoscopic gastrostomy tube: an underestimated burden on patients and the health care system. Surg Endosc. 2011;25:3307–3311.

Galat SA, Gerig KD, Porter JA, Slezak FA. Management of premature removal of the percutaneous gastrostomy. Am Surg 1990; 56:733.

Schrag SP, Sharma R, Jaik NP, Seamon MJ, Lukaszczyk JJ, Martin ND, Hoey BA, Stawicki SP. Complications related to percutaneous endoscopic gastrostomy (PEG) tubes. A comprehensive clinical review. J Gastrointestin Liver Dis. 2007;16:407–418.

Ahmad J, Thomson S, McFall B, Scoffield J, Taylor M. Colonic injury following percutaneous endoscopic-guided gastrostomy insertion. BMJ Case Rep. 2010;2010.

Nazarian A, Cross W, Kowdley GC. Pneumoperitoneum after percutaneous endoscopic gastrostomy among adults in the intensive care unit: incidence, predictive factors, and clinical significance. Am Surg 2012;78:591–4.

Murphy CJ, Adler DG, Cox K, et al. . Insufflation with carbon dioxide reduces pneumoperitoneum after percutaneous endoscopic gastrostomy (PEG): a randomized controlled trial. Endosc Int Open 2016;4:E292–5. 10.1055/s-0042-100192.

Warriner L, Spruce P. Managing overgranulation tissue around gastrostomy sites. Br J Nurs. 2012;21:S14–S6, S18, S20.

Schrag SP, Sharma R, Jaik NP, Seamon MJ, Lukaszczyk JJ, Martin ND, Hoey BA, Stawicki SP. Complications related to percutaneous endoscopic gastrostomy (PEG) tubes. A comprehensive clinical review. J Gastrointestin Liver Dis. 2007;16:407–418.

Bechtold ML, Matteson ML, Choudhary A, et al. Early versus delayed feeding after placement of a percutaneous endoscopic gastrostomy: a meta-analysis. Am J Gastroenterol 2008; 103:2919.

St-Louis E, Safa N, Guadagno E, et al. . Gastrocutaneous fistulae in children - A systematic review and meta-analysis of epidemiology and treatment options. J Pediatr Surg 2018;53:946–58. 10.1016/j.jpedsurg.2018.02.022.

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5 Nisan 2022

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