Brakiyal Pleksopatiler
Özet
Brakiyal pleksopatiler, brakiyal pleksusun travmatik veya non-travmatik nedenlerle hasarlanması sonucu ortaya çıkan, üst ekstremitede kas güçsüzlüğü ve duyu anormallikleri ile seyreden hastalıklardır. Anatomiye bakıldığında pleksus; C5-T1 köklerinin ventral dallarından oluşur; trunkus, divizyon, kord ve periferik sinirler şeklinde ilerler. Etiyolojide Erb-Duchenne/Klumpke paralizileri gibi obstetrik travmalar, künt/penetran yaralanmalar, omuz çıkıkları, tümör invazyonları (Pancoast tümörü), radyasyon hasarı ve nöraljik amyotrofi gibi inflamatuar süreçler yer alır. Tanıda öykü ve nörolojik muayenenin yanı sıra lokalizasyon ile prognozu belirleyen sinir iletim çalışmaları ve iğne EMG en önemli elektrodiagnostik testlerdir. Radikülopatilerden farklı olarak paraspinal kasların normal, duyu sinir aksiyon potansiyellerinin (BSAP) ise anormal olması beklenir. Görüntülemede MRG ve MR nörografi; infiltratif lezyonları, ödemi ve kontrastlanmayı göstermede BT'ye göre daha duyarlıdır. Tedavi yaklaşımları ise altta yatan etiyolojiye göre cerrahi dekompresyon, tümör tedavisi, analjezikler ve fizik tedavi uygulamalarını kapsamaktadır.
Brachial plexopathies are disorders resulting from traumatic or non-traumatic injury to the brachial plexus, presenting with muscle weakness and sensory abnormalities in the upper extremity. Anatomically, the plexus is formed by the ventral rami of the C5-T1 roots and progresses as trunks, divisions, cords, and peripheral nerves. The etiology includes obstetric traumas such as Erb-Duchenne/Klumpke palsies, blunt/penetrating injuries, shoulder dislocations, tumor invasions (Pancoast tumor), radiation damage, and inflammatory processes like neuralgic amyotrophy. In diagnosis, along with history and neurological examination, nerve conduction studies and needle EMG are the most crucial electrodiagnostic tests for determining localization and prognosis. Unlike radiculopathies, paraspinal muscles are expected to be normal, while sensory nerve action potentials (SNAP) are abnormal. In imaging, MRI and MR neurography are more sensitive than CT in demonstrating infiltrative lesions, edema, and contrast enhancement. Treatment approaches encompass surgical decompression, tumor management, analgesics, and physical therapy, depending on the underlying etiology.
Referanslar
Gilcrease-Garcia BM, Deshmukh SD, Parsons MS. Anatomy, Imaging, and Pathologic Conditions of the Brachial Plexus. Radiographics 2020; 40(6): 1686-1714.
Rubin DI. Brachial and lumbosacral plexopatihes: A review. Clin Neurolphysiol Pract 2020; 5:173-193.
Ferrante MA. Brachial plexopathies. Continuum (Minneap Minn) 2014; 20(5 Peripheral Nervous System Disorders): 1323-1342.
Ferrante MA. Brachial plexopathies: classification, causes, and consequences. Muscle Nerve 2004;30(5):547-568.
Tharin BD, Kini JA, York GE, Ritter JL. Brachial plexopathy: a review of traumatic and nontraumatic causes. AJR Am J Roentgenol 2014; 202(1): W67-75.
Swash M. Diagnosis of brachial root and plexus lesions. J Neurol 1986;233(3): 131-135.
Strakowski JA. Electrodiagnosis of plexopathy. PMR 2013; 5(Suppl 5): 50-55.
Seddon HJ. A Classification of Nerve Injuries. Br Med J 1942; 2(4260): 237-239.
Sunderland S. A classification of peripheral nerve injuries producing loss of function. Brain 1951; 74(4):491-516.
Van Eijk JJ, Groothuis JT, Van Alfen N. Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment. Muscle Nerve 2016; 53(3): 337-350.
Gutkowska O, Martynkiewicz J, Urban M, Gosk J. Brachial plexus injury after shoulder dislocation: a literature review. Neurosurg Rev 2020; 43(2): 407-423.
Jaeckle KA. Neurolgic manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol 2010; 30(3): 254-262.
Kori SH, Foley KM, Posner JB. Brachial plexus lesions in patients with cancer: 100 cases. Neurology 1981; 31(1): 45-50.
Gwathmey KG. Plexus and peripheral nerve metastasis. Handb Clin Neurol 2018; 149: 257-279.
Alfonso I, Alfonso DT, Papazian O. Focal upper extremity neuropathy in neonates. Semin Pediatr Neurol 2000; 7(1): 4-14.
Levin KH, Wilbourn AJ, Maggiano HJ. Cervical rib and median sternotomy-related brachial plexopathies: a reassessment. Neurology 1998; 50(5): 1407-1413.
Fisher MA. F-wave studies: Clinical utility. Muscle Nerve 1998;21: 1098-1101.
Dhawan PS. Electrodiagnostic Assessment of Plexopathies. Neurol Clin 2021; 39(4): 997-1014.
Li JM, Tavee J. Electrodiagnosis of radiculopathy. Handb Clin Neurol 2019; 161:305-316.
Levin KH. Approach to the patient with suspected radiculopathy. Neurol Clin 2012; 30(2): 581-604.
Katirji MB, Wilbourn AJ. Common peroneal mononeuropathy: a clinical and electrophysiologic study of 116 lesions. Neurology 1988;38:1723-8.
Masakado Y, Kawakami M, Suzuki K, Abe L, Ota T, Kimura A. Clinical neurophysiology in the diagnosis of peroneal nerve palsy. Keio J Med 2008;57:84-9.
Crim J, Ingalls K. Accuracy of MR neurography in the diagnosis of brachial plexopathy. Eur J Radiol 2017; 95: 24–27.
Griffith JF. Ultrasound of the Brachial Plexus. Semin Musculoskelet Radiol 2018; 22(3): 323-333.
Baute V, Strakowski JA, Reynolds JW, Karvelas KR, Ehlers P, Brenzy KJ, et al. Neuromuscular ultrasound of the brachial plexus: a standardized approach. Muscle Nerve 2018; 58(5): 618–624.
Gilbert A, Tassin J. Surgical repair of the brachial plexus in obstetric paralysis. Chirurgie 1984: 110 (1); 70–75.
Yang LJS. Neonatal brachial plexus palsy-Management and prognostic factors. Semin Perinatol 2014; 38 (4): 222–234.
Pitt M, Vredeveld JW. The role of electromyography in the management of the brachial plexus palsy of the newborn. Clin. Neurophys 2005; 116 (8): 1756–1761.
Robinson CM, Shur N, Sharpe T, Ray A, Murray IR. Injuries associated with traumatic anterior glenohumeral dislocations. J Bone Joint Surg Am 2012; 94:18–26.
de Laat EA, Visser CP, Coene LN, Pahlplatz PV, Tavy DL. Nerve lesions in primary shoulder dislocations and humeral neck fractures. A prospective clinical and EMG study. J Bone Joint Surg Br 1994; 76(3):381–383.
Yeap JS, Lee DJ, Fazir M, Kareem BA, Yeap JK. Nerve injuries in anterior shoulder dislocations. Med JMalaysia 2004; 59(4):450–454.
Pasila M, Kiviluoto O, Jaroma H, Sundholm A. Recovery from primary shoulder dislocation and its complications. Acta Orthop Scand 1980; 51(2):251–257.
Thomas BE, McCullen GM, Yuan HA. Cervical spine injuries in football players. J Am Acad Orthop 1999; 7 (5): 338–347.
Dorhout Mees SM, Faals NL, Alfen N. Backpack palsy and other brachial plexus neuropathies in the military population. J Peripher Nerv Syst 2020; 25 (1): 27–31.
Moghekar AR, Moghekar AR, Karli N, Chaudhry V. Brachial plexopathies: etiology, frequency, and electrodiagnostic localization. J Clin neuromuscul Dis 2007; 9(1): 243-247.
Kim DH, Cho YJ, Tiel RL, Kline DG. Outcomes of surgery in 1019 brachial plexus lesions treated at Louisiana State University Health Sciences Center. J Neurosurg 2003; 98(5): 1005-1016.
Wilbourn AJ. Electrodiagnosis of plexopathies. Neurol Clin 1985; 3 (3): 511–529.
Ferrante MA. The thoracic outlet syndromes. Muscle Nerve 2012;45(6):780-795.
Gilliatt RW, Le Quesne PM, Logue V, Sumner AJ. Wasting of the hand associated with a cervical rib or band. J Neurol Neurosurg Psychiatr 1970;33(5):615-624.
Katirji B, Hardy RW Jr. Classic neurogenic thoracic outlet syndrome in a competitive swimmer: a true scalenus anticus syndrome. Muscle Nerve 1995;18(2):229-233.
Ferrante MA, Ferrante ND. The thoracic outlet syndromes: Part 1. Overview of the thoracic outlet syndromes and review of true neurogenic thoracic outlet syndrome. Muscle Nerve 2017; 55 (6): 782–793.
van Alfen N, Malessy MJ. Diagnosis of brachial and lumbosacral plexus lesions. Handb Clin Neurol 2013; 115:293-310.
Thyagarajan D, Cascino T, Harms G. Magnetic resonance imaging in brachial plexopathy of cancer. Neurology 1995; 45: 421–427.
Taylor BV, Kimmel DW, Krecke KN et al. Magnetic resonance imaging in cancer-related lumbosacral plexopathy. Mayo Clin Proc 1997; 72: 823–829.
van Es HW, Engelen AM, Witkamp TD, Ramos LMP, Feldberg MAM. Radiation-induced brachial plexopathy: MR imaging. Skeletal Radiol 1997; 26 (5): 284–288.
Weiler-Sagie M, Bushelev O, Epelbaum R, Dann EJ, Haim N, Avivi I, et al. 18F-FDG avidity in lymphoma readdressed: a study of 766 patients. J. Nucl. Med 2010; 51 (1): 25–30.
Yan M, Kong W, Kerr A, Brundage M. The radiation dose tolerance of the brachial plexus: a systematic review and meta-analysis. Clin Transl Radiat Oncol 2019; 18: 23–31.
Emami B, Lyman J, Brown A, Cola L, Goitein M, Munzenrider JE. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991; 21 (1): 109-122.
Krarup C, Crone C. Neurophysiological studies in malignant disease with particular reference to involvement of peripheral nerves. J Neurol 2002; 249 (6): 651-661.
Harper CM, Thomas JE, Cascino TL, Litchy WJ. Distinction between neoplastic and radiation-induced brachial plexopathy, with emphasis on the role of EMG. Neurology 1989; 39 (4): 502–506.
Mondrup K, Olsen NK, Pfeiffer P, et al. Clinical and electrodiagnostic findings in breast cancer patients with radiation-induced brachial plexus neuropathy. Acta Neurol Scand 1990;81:153–158.
Roth G, Magistris MR, Le Fort D et al. Post-radiation branchial plexopathy Persistent conduction block. Myokymic discharges and cramps. Rev Neurol (Paris) 1988; 144: 173–180.
Soto O. Radiation-induced conduction block: resolution following anticoagulant therapy. Muscle Nerve 2005; 31 (5): 642-645.
Glantz MJ, Burger PC, Friedman AH, et al. Treatment of radiation-induced nervous system injury with heparin and warfarin. Neurology 1994;44:2020–2027
Stowe HB, Mullins BT, Chera BS. Hyperbaric oxygen therapy for radiation-induced brachial plexopathy, a case report and literature review. Rep Pract Oncol Radiother 2020; 25 (1): 23–27.
Pritchard J, Anand P, Broome J, Davis C, Gothard L, Hall E, et al. Doubleblind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol 2001; 58 (3): 279-286.
Parsonage MJ, Turner JW. Neuralgic amyotrophy; the shoulder-girdle syndrome. Lancet 1948;1:973–978.
van Alfen N, van Engelen BG. The clinical spectrum of neuralgic amyotrophy in 246 cases. Brain 2006;129:438–450.
Pellegrino JE, Rebbeck TR, Brown MJ, Bird TD, Chance PF. Mapping of hereditary neuralgic amyotrophy (familial brachial plexus neuropathy) to distal chromosome 17q. Neurology 1996;46:1128–1132.
Klein CJ, Wu Y, Cunningham JM, et al. SEPT9 mutations and a conserved 17q25 sequence in sporadic and hereditary brachial plexus neuropathy. Arch Neurol 2009;66(2):238–243.
Van Alfen N. Clinical and pathophysiological concepts of neuralgic amyotrophy. Nat Rev Neurol 2011;7:315–322.
van Alfen N, van Eijk JJ, Ennik T, Flynn SO, Nobacht IE, Groothuis JT, et al. Incidence of neuralgic amyotrophy (Parsonage Turner syndrome) in a primary care setting—a prospective cohort study. PLoS One 2015;10:e0128361.
Van Alfen N, Schuuring J, van Engelen BG, Rotteveel JJ, Gabreels FJ. Idiopathic neuralgic amyotrophy in children. A distinct phenotype compared to the adult form. Neuropediatrics 2000;31:328–332.
Yamada K, Mano T, Toribe Y, Yanagihara K, Suzuki Y. MRI findings and steroid therapy for neuralgic amyotrophy in children. Pediatr Neurol 2011;45:200–202.
Seror P. Neuralgic amyotrophy. An update. Joint Bone Spine 2017; 84 (2): 153-158.
Van Eijk JJ, Groothuis JT, Van Alfen N. Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment. Muscle Nerve 2016; 53(3): 337-350.
Dartevel A, Colombe B, Bosseray A, Larrat S, Sarrot-Reynauld F, Belbezier A, et al. Hepatitis E and neuralgic amyotrophy: five cases and review of literature. J Clin Virol 2015;69:156–164.
van Eijk JJ, Madden RG, van der Eijk AA, Hunter JG, Reimerink JH, Bendall RP, et al. Neuralgic amyotrophy and hepatitis E virus infection. Neurology 2014;82:498–503.
Bardos V, Somodska V. Epidemiologic study of a brachial plexus neuritis outbreak in northeast Czechoslovakia. World Neurol 1961;2:973– 979
Suarez GA, Giannini C, Bosch EP, Barohn RJ, Wodak J, Ebeling P, et al. Immune brachial plexus neuropathy: suggestive evidence for an inflammatory-immune pathogenesis. Neurology 1996;46:559–561.
Pan Y, Wang S, Zheng D, Tian W, Tian G, Ho PC, et al. Hourglasslike constrictions of peripheral nerve in the upper extremity: a clinical review and pathological study. Neurosurgery 2014;75:10–22.
Vriesendorp FJ, Dmytrenko GS, Dietrich T, Koski CL. Anti-peripheral nerve myelin antibodies and terminal activation products of complement in serum of patients with acute brachial plexus neuropathy. Arch Neurol 1993;50:1301–1303
Sierra A, Prat J, Bas J, Romeu A, Montero J, Matos JA, et al. Blood lymphocytes are sensitized to branchial plexus nerves in patients with neuralgic amyotrophy. Acta Neurol Scand 1991;83:183–186.
van Alfen N, Huisman WJ, Overeem S, van Engelen BG, Zwarts MJ. Sensory nerve conduction studies in neuralgic amyotrophy. Am J Phys Med Rehabil 2009;88:941–946.
Panagopoulos N, Leivaditis V, Koletsis E, Prokakis C, Alexopoulos P, Baltayiannis N, et al. Pancoast tumors: characteristics and preoperative assessment. J Thorac Dis 2014;6(suppl 1):S108–115.
Tsao BE, Ostrovskiy DA, Wilbourn AJ, Shields RW Jr. Phrenic neuropathy due to neuralgic amyotrophy. Neurology 2006;66:1582–1584.
Jawdat O, Statland JM, Barohn RJ, Katz J, Dimachkie MM. ALS Regional Variants (Brachial Amyotrophic Diplegia, Leg Amyotrophic Diplegia, and Isolated Bulbar Amyotrophic Lateral Sclerosis). Neurol Clin 2015; 33(4): 775-785.
Seror P, Lenglet T, Nguyen C, Ouaknine M, Lefevre-Colau MM. Unilateral winged scapula: Clinical and electrodiagnostic experience with 128 cases, with special attention to long thoracic nerve palsy. Muscle Nerve 2018;57(6):913-920.