Erythrocytes, Leukocytes, Platelets In Obesity and Metabolic Syndrome
Özet
This text investigates the diagnostic and prognostic value of complete blood cell count (CBC) parameters—including erythrocytes (RBC), leukocytes (WBC), platelets (PLT), and their associated indices—in relation to obesity and metabolic syndrome (MetS) across adult and pediatric populations. Chronic, low-grade inflammation inherent in obesity drives the exploration of these standard hematological variables as accessible indicators of proinflammatory and thrombogenic states. Key findings indicate that obese individuals and those with MetS exhibit distinct alterations, such as elevated hematocrit and red blood cell distribution width (RDW), which correlate strongly with cardiovascular disease risks, atherosclerosis, and iron regulatory anomalies like increased hepcidin expression. Furthermore, leukocytic patterns, particularly neutrophil and eosinophil counts, reveal critical gender-specific differences; for instance, elevated eosinophils in morbidly obese boys act as early predictors of future cardiometabolic complications, while neutrophil recruitment patterns differ significantly during advanced obesity stages. Platelet profiles and markers like plateletcrit also mirror total body fat mass and link insulin resistance to heightened thrombotic states and endothelial dysfunction. Ultimately, the study concludes that because obesity markedly alters hematological structures, existing reference intervals should be updated to establish specific "normal" baseline values tailored to obese patients and distinct genders.
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