Gebelikte Acil Cerrahi Durumlar

Yazarlar

Ümit Özdemir
https://orcid.org/0000-0001-5681-7421

Özet

Gebelikte obstetrik olmayan cerrahi girişim ihtiyacı, yaklaşık %1 oranında görülmekte olup en sık apandisit ve kolesistit gibi akut batın patolojileri nedeniyle ortaya çıkmaktadır. Cerrahi müdahaleler, acil durumlarda fetusun içinde bulunduğu trimester dönemine bakılmaksızın derhal uygulanmalıdır; ancak doğumu bekleyemeyecek elektif dışı işlemlerde organogenezin tamamlandığı ikinci trimester en güvenli dönem olarak kabul edilir. Anestezik ilaçların insanlarda doğrudan teratojenik etkisi kanıtlanmamış olsa da progesteron seviyesini düşüren sugammadeks kullanımından kaçınılması önerilir. Cerrahi operasyonlar erken doğum, düşük doğum ağırlığı ve ölü doğum gibi obstetrik riskleri ılımlı düzeyde artırabilir; fakat enfeksiyöz patolojilerde müdahalenin geciktirilmesi anne ve fetus için çok daha yüksek mortalite riski taşır. Preoperatif dönemde trombofili riskine karşı mekanik veya farmakolojik tromboprofilaksi uygulanmalı, postoperatif süreçte ise sol lateral pozisyon, etkin ağrı yönetimi ve fetal kalp atımı takibi titizlikle sürdürülmelidir. Apandisitte zamanında cerrahi, perforasyon kaynaklı fetal kayıpları önlemede kritik öneme sahipken, akut kolesistit ve biliyer pankreatit durumlarında da konservatif yaklaşım yerine cerrahi ilk seçenek haline gelmiştir. Sonuç olarak, gebelikte acil cerrahi yönetim; multidisipliner bir yaklaşım, klinik şüphe, erken tanı ve gecikmesiz operasyonla anne ile fetus güvenliğini optimal düzeyde sağlamayı amaçlar.

The need for non-obstetric surgery during pregnancy occurs in approximately 1% of gestations, predominantly driven by acute abdominal pathologies such as appendicitis and cholecystitis. Emergency surgical interventions must be performed immediately regardless of the gestational trimester, whereas for operations that cannot wait until delivery, the second trimester is preferred to minimize risks to organogenesis. While anesthetic agents lack proven teratogenic effects in humans, the routine use of sugammadex should be avoided due to its potential to lower progesterone levels. Surgical procedures moderately increase obstetric complications, including preterm labor, low birth weight, and stillbirth; however, delaying treatment for infectious conditions poses a significantly higher risk of maternal and fetal mortality. Preoperatively, thromboprophylaxis is essential to counteract the hypercoagulable state of pregnancy, while postoperative care requires strict adherence to left lateral positioning, multimodal analgesia, and close monitoring of fetal heart rate. Prompt appendectomy is vital to prevent perforation-related fetal loss, and surgery has increasingly become the primary choice over conservative management for cholecystitis and biliary pancreatitis. Ultimately, managing surgical emergencies in pregnant patients requires high clinical suspicion, timely diagnosis, and a multidisciplinary approach to ensure both maternal and fetal safety.

Referanslar

Balinskaite V, Bottle A, Sodhi V, et al. The risk of adverse pregnancy outcomes following nonobstetric surgery during pregnancy: estimates from a retrospective cohort study of 6.5 million pregnancies. Annals of Surgery. 2017;266(2):260-6.

Jenkins TM, Mackey SF, Benzoni EM, et al. Non‐obstetric surgery during gestation: Risk factors for lower birthweight. Australian and New Zealand journal of obstetrics and gynaecology. 2003;43(1):27-31.

Rasmussen AS, Christiansen CF, Uldbjerg N, et al. Obstetric and non-obstetric surgery during pregnancy: a 20-year Danish population-based prevalence study. BMJ open. 2019;9(5):e028136.

Willett AW, Butwick AJ, Togioka B, et al. Society for Obstetric Anesthesia and Perinatology Statement on sugammadex during pregnancy and lactation. 2019. Accessed February 24, 2021.

Mazze RI, Kallén B. Reproductive outcome after anesthesia and operation during pregnancy: a registry study of 5405 cases. American journal of obstetrics and gynecology. 1989;161(5):1178-85.

Lind JN, Interrante JD, Ailes EC, et al. Maternal use of opioids during pregnancy and congenital malformations: a systematic review. Pediatrics. 2017;139(6).

Rasmussen AS, Christiansen CF, Ulrichsen SP, et al. Non‐obstetric abdominal surgery during pregnancy and birth outcomes: A Danish registry‐based cohort study. Acta Obstetricia et Gynecologica Scandinavica. 2020;99(4):469-76.

Carvalho B. Nonobstetric surgery during pregnancy. IARS 2006 review course lectures 2006, pp 23-30.

Alkiş İ, Kurdoğlu M, Kurdoğlu Z. Nonobstetric surgical intervention in pregnancy. Eastern Journal of Medicine. 2010;15(1):1-6.

Higgins MF, Pollard L, McGuinness SK, et al. Fetal heart rate monitoring in nonobstetric surgery: a systematic review of the evidence. American Journal of Obstetrics & Gynecology MFM. 2019;1(4):100048.

McCurdy RJ. Intraoperative fetal monitoring for nonobstetric surgery. Clinical Obstetrics and Gynecology. 2020;63(2):370-8.

Walton NKD, Melachuri VK. Anaesthesia for non-obstetric surgery during pregnancy. Continuing Education in Anaesthesia, Critical Care & Pain. 2006;6(2):83-5.

Ducloy-Bouthors AS, Baldini A, Abdul-Kadir R, et al. ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Surgery during pregnancy and the immediate postpartum period. European Journal Anaesthesiology. 2018;35(2):130-3.

Antonucci R, Zaffanello M, Puxeddu E, et al. Use of non-steroidal anti-inflammatory drugs in pregnancy: impact on the fetus and newborn. Current drug metabolism. 2012;13(4):474-90.

Abbasi N, Patenaude V, Abenhaim HA. Management and outcomes of acute appendicitis in pregnancy—population‐based study of over 7000 cases. BJOG: An International Journal of Obstetrics & Gynaecology. 2014;121(12):1509-14.

Babaknia A, Parsa H, Woodruff JD. Appendicitis during pregnancy. Obstetrics & Gynecology. 1977;50(1):40-1.

Cunningham FG, McCubbin JH. Appendicitis complicating pregnancy. Obstetrics and Gynecology. 1975;45(4):415-20.

Augustin G, Majerovic M. Non-obstetrical acute abdomen during pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2007;131(1):4-12.

Taylor DJ, Phillips P, Lind T. Puerperal haematological indices. BJOG: An International Journal of Obstetrics & Gynaecology. 1981;88(6):601-6.

Yeomans ER, Gilstrap Iii LC. Physiologic changes in pregnancy and their impact on critical care. Critical care medicine. 2005;33(10):S256-S8.

Gentles JQ, Meglei G, Chen L, et al. Is neutrophilia the key to diagnosing appendicitis in pregnancy? The American Journal of Surgery. 2020;219(5):855-9.

Tamir IL, Bongard FS, Klein SR. Acute appendicitis in the pregnant patient. The American Journal of Surgery. 1990;160(6):571-6.

Yilmaz HG, Akgun Y, Bac B, et al. Acute appendicitis in pregnancy—risk factors associated with principal outcomes: a case control study. International Journal of Surgery. 2007;5(3):192-7.

Al-Mulhim AA. Acute appendicitis in pregnancy. A review of 52 cases. International surgery. 1996;81(3):295-7.

Pastore PA, Loomis DM, Sauret J. Appendicitis in pregnancy. The Journal of the American Board of Family Medicine. 2006;19(6):621-6.

Aggenbach L, Zeeman GG, Cantineau AEP, et al. Impact of appendicitis during pregnancy: no delay in accurate diagnosis and treatment. International Journal of Surgery. 2015;15:84-9.

Basso L, McCollum PT, Darling MR, et al. A study of cholelithiasis during pregnancy and its relationship with age, parity, menarche, breast-feeding, dysmenorrhea, oral contraception and a maternal history of cholelithiasis. Surgery, Gynecology & Obstetrics. 1992;175(1):41-6.

Cosenza CA, Saffari B, Jabbour N, et al. Surgical management of biliary gallstone disease during pregnancy. The American Journal of Surgery. 1999;178(6):545-8.

Jelin EB, Smink DS, Vernon AH, et al. Management of biliary tract disease during pregnancy: a decision analysis. Surgical Endoscopy. 2008;22(1):54-60.

Muench J, Albrink M, Serafini F, et al. Delay in treatment of biliary disease during pregnancy increases morbidity and can be avoided with safe laparoscopic cholecystectomy/Discussion. The American Surgeon. 2001;67(6):539.

Lu EJ, Curet MJ, El-Sayed YY, et al. Medical versus surgical management of biliary tract disease in pregnancy. The American Journal of Surgery. 2004;188(6):755-9.

Gouldman JW, Sticca RP, Rippon MP, et al. Laparoscopic cholecystectomy in pregnancy/Discussion. The American Surgeon. 1998;64(1):93.

Fatum M, Rojansky N. Laparoscopic surgery during pregnancy. Obstetrical & Gynecological Survey. 2001;56(1):50-9.

Printen KJ, Ott RA. Cholecystectomy during pregnancy. The American Surgeon. 1978;44(7):432-4.

Tham TCK, Vandervoort J, Wong RCK, et al. Safety of ERCP during pregnancy. The American Journal of Gastroenterology. 2003;98(2):308-11.

Jamidar PA, Beck GJ, Hoffman BJ, et al. Endoscopic retrograde cholangiopancreatography in pregnancy. American Journal of Gastroenterology (Springer Nature). 1995;90(8).

Matsuda Y, Maeda T, Hatae M. Spontaneous rupture of the liver in an uncomplicated pregnancy. Journal of Obstetrics and Gynaecology Research. 1997;23(5):449-52.

Saura P, Blanch LL, Capdevila E, et al. Spontaneous rupture of the liver during pregnancy. Intensive Care Medicine. 1995;21(1):95-6.

Smith Jr LG, Moise Jr KJ, Dildy 3rd GA, et al. Spontaneous rupture of liver during pregnancy: current therapy. Obstetrics and Gynecology. 1991;77(2):171-5.

Connolly MM, Unti JA, Nora PF. Bowel obstruction in pregnancy. Surgical Clinics of North America. 1995;75(1):101-13.

Preis K, Kopiejć A, Dudziak M, et al. Intestinal obstruction during pregnancy. Ginekologia Polska. 2013;84(2).

Perdue PW, Johnson Jr HW, Stafford PW. Intestinal obstruction complicating pregnancy. The American Journal of Surgery. 1992;164(4):384-8.

Montes H, Wolf J. Cecal volvulus in pregnancy. The American Journal of Gastroenterology. 1999;94(9):2554-6.

Perrot L, Fohlen A, Alves A, et al. Management of the colonic volvulus in 2016. Journal of Visceral Surgery. 2016;153(3):183-92.

Eddy JJ, Gideonsen MD, Song JY, et al. Pancreatitis in Pregnancy: a 10 year retrospective of 15 Midwest Hospitals. Obstetrics and Gynecology. 2008;112(5):1075.

Pitchumoni CS, Yegneswaran B. Acute pancreatitis in pregnancy. World Journal of Gastroenterology: WJG. 2009;15(45):5641.

Scott LD. Gallstone disease and pancreatitis in pregnancy. Gastroenterology Clinics of North America. 1992;21(4):803-15.

Gelecek

19 Eylül 2022

Lisans

Lisans