Diyabetik Ayak: Diyabetik Ayakta Görüntüleme Yöntemleri
Özet
Diyabetik ayak, diyabetes mellitusun en ciddi komplikasyonlarından biri olup erken tanı ve çok disiplinli yaklaşım gerektirir. Tanısal görüntülemede temel amaç, osteomiyelit ile nöropatik osteoartropati ayrımını doğru yaparak amputasyon riskini azaltmaktır. İlk değerlendirmede kolay ulaşılabilir ve ucuz olan direkt radyografi tercih edilir; bu yöntem kemik anormalliklerini, yumuşak dokudaki gaz ve yabancı cisimleri saptamada etkilidir ancak erken evrelerde duyarlılığı düşüktür. Ultrasonografi (US), periferik arter hastalığının (PAH) erken teşhisinde, vasküler haritalamada ve apse gibi yumuşak doku enfeksiyonlarının hızlı değerlendirilmesinde önemli rol oynar. Manyetik Rezonans Görüntüleme (MRG), yüksek doku çözünürlüğü sayesinde kemik iliği ödemini, yumuşak doku tutulumlarını gösteren ve osteomiyelit ile nöropatik artropati ayrımında en üstün olan altın standart yöntemdir. Bilgisayarlı tomografi (BT) ise kemik erozyonlarını ve sklerozu değerlendirmede kullanılır. Kritik ayak iskemisinde diz altı arterlerdeki darlık ve tıkanıklıkları saptamak için Doppler US, BT/MR anjiyografi ve konvansiyonel anjiyografi gibi yöntemlerden yararlanılır; revaskülarizasyon planlanan hastalarda anjiyografi kritik önem taşır. Erken teşhis ve uygun tedavi komplikasyonları önlemede hayatidir.
Diabetic foot is one of the most serious complications of diabetes mellitus, requiring early diagnosis and a multidisciplinary approach. The primary goal in diagnostic imaging is to differentiate between osteomyelitis and neuropathic osteoarthropathy accurately, thereby reducing the risk of amputation. Direct radiography, which is easily accessible and inexpensive, is preferred in the initial evaluation; this method is effective in detecting bone abnormalities, soft tissue gas, and foreign bodies, but its sensitivity is low in the early stages. Ultrasonography (US) plays an important role in the early detection of peripheral arterial disease (PAD), vascular mapping, and rapid evaluation of soft tissue infections such as abscesses. Magnetic Resonance Imaging (MRI) is the gold standard method that is superior in differentiating between osteomyelitis and neuropathic arthropathy, as it clearly demonstrates bone marrow edema and soft tissue involvement thanks to its high tissue resolution. Computed tomography (CT) is used to evaluate bone erosions and sclerosis. To detect stenoses and occlusions in the infrapopliteal arteries in critical foot ischemia, methods such as Doppler US, CT/MR angiography, and conventional angiography are utilized; angiography is of critical importance in patients for whom revascularization is planned. Early diagnosis and appropriate treatment are vital in preventing complications.
Referanslar
Davies M, Brophy S, Williams R, Taylor A. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 2006;29(7):1518–1522).
Kilicoglu G, Kilicoglu OI. Imaging of the diabetic foot. TOTBİD Dergisi 2015; 14:363–376 doi: 10.14292/totbid.dergisi.2015.55
Yvonne Cheung, Mary Hochman, David P. Brophy. The Diabetic Foot. 2002; Medical and Surgical Management. Radiographic Changes of the Diabetic Foot. Pages 179-205
Ergen FB, Sanverdi SE, Oznur A. Charcot foot in diabetes and an update on imaging. Diabet Foot Ankle. 2013;4:10.3402/dfa.v4i0.21884. Published 2013 Nov 20. doi:10.3402/dfa.v4i0.21884
Arnon-Sheleg E,Keidar Z. Diabetic Foot Infection: The Role of PET/CT Imaging. Curr Pharm Des.2018;24(12):1277-1286.doi:10.2174/1381612824666180227095439
Gnanasegaran G, Vijayanathan S, Fogelman I. Diagnosis of infection in the diabetic foot using (18)F-FDG PET/CT: a sweet alternative? Eur J Nucl Med Mol Imaging. 2012 Oct;39(10):1525-7. doi: 10.1007/s00259-012-2234-5. PMID: 22965247.
Yaddanapudi K, Matthews R, Brunetti V, Martin B, Franceschi D. PET-MRI in diagnosing pedal osteomyelitis in diabetic patients. J Nucl Med 2015;56(suppl 3):307.
Donovan A, Schweitzer ME. Use of MR imaging in diagnosing diabetes-related pedal osteomyelitis. RadioGraphics 2010;30(3):723–736).
El-Maghraby TA, Moustafa HM, Pauwels EK. Nuclear medicine methods forevaluation of skeletal infection among other diagnostic modalities. Q J Nucl Med MolImaging 2006; 50: 167–192.
Hochman et al. Imaging of the Diabetic Foot. The Diabetic Foot, Second Edition Edited by: A. Veves, J. M. Giurini, and F. W. LoGerfo © Humana Press Inc., Totowa, NJ
Bonakdar-pour A, Gaines VD. The radiology of osteomyelitis. Orthop Clin North Am 1983;14:21–37
Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376:2367-2375
Armstrong DG, Swerdlow MA, Armstrong AA, Conte MS, Padula WV, Bus SA. Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res. 2020;13:16
Potier L, Abi Khalil C, Mohammedi K, Roussel R. Use and utility of ankle brachial index in patients with diabetes. Eur J Vasc Endovasc Surg. 2011;41(1):110-116. doi:10.1016/j.ejvs.2010.09.020
Williams DT, Harding KG, Price P. An evaluation of the efficacy of methods used in screening for lower-limb arterial disease in diabetes. Diabetes Care. 2005;28:2206-2210
Tehan PE, Sebastian M, Barwick AL, Chuter VH. How sensitive and specific is continuous-wave Doppler for detecting peripheral arterial disease in people with and without diabetes? A cross-sectional study. Diab Vasc Dis Res. 2018;15:396-401
Hinchliffe RJ, Forsythe RO, Apelqvist J, et al. Guidelines on diagnosis, prognosis, and management of peripheral artery disease in patients with foot ulcers and diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36(suppl 1):e3276
Pieruzzi L, Napoli V, Goretti C, Adami D, Iacopi E, Cicorelli A, Piaggesi A. Ultrasound in the Modern Management of the Diabetic Foot Syndrome: A Multipurpose Versatile Toolkit. Int J Low Extrem Wounds. 2020 Dec;19(4):315-333
Williams DT, Price P, Harding KG. The influence of diabetes and lower limb arterial disease on cutaneous foot perfusion. J Vasc Surg. 2006;44:770-775
Hsu CC, Tsai WC, Shau YW, Lee KL, Hu CF. Altered energy dissipation ratio of the plantar soft tissues under the metatarsal heads in patients with type 2 diabetes mellitus: a pilot study. Clin Biomech (Bristol, Avon). 2007;22:67-73
Caputo GM, Cavanagh PR, Ulbrecht JS, Gibbons GW, Karchmer AW. Assessment and management of foot disease in patients with diabetes. N Engl J Med. 1994;331:854-860.
Lipsky BA, Peters EJ, Senneville E, et al. Expert opinion on the management of infections in the diabetic foot. Diabetes Metab Res Rev. 2012;28(suppl 1):163-178
Iacopi E, Coppelli A, Goretti C, Piaggesi A. Necrotizing fasciitis and the diabetic foot. Int J Low Extrem Wounds. 2015;14:316-327
Frazee BW, Fee C, Lynn J, et al. Community-acquired necrotizing soft tissue infections: a review of 122 cases presenting to a single emergency department over 12 years. J Emerg Med. 2008;34:139-146
Martín Noguerol T, Luna Alcalá A, Beltrán LS, Gómez Cabrera M, Broncano Cabrero J, Vilanova JC. Advanced MR Imaging Techniques for Differentiation of Neuropathic Arthropathy and Osteomyelitis in the Diabetic Foot. Radiographics. 2017 Jul-Aug;37(4):1161-1180. doi: 10.1148/rg.2017160101. PMID: 28696850.
Sanverdi SE, Ergen BF, Oznur A. Current challenges in imaging of the diabetic foot. Diabet Foot Ankle. 2012;3. doi: 10.3402/dfa.v3i0.18754. Epub 2012 Oct 1. PMID: 23050068; PMCID: PMC3464078.
Low KT, Peh WC. Magnetic resonance imaging of diabetic foot complications. Singapore Med J. 2015 Jan;56(1):23-33; quiz 34. doi: 10.11622/smedj.2015006. PMID: 25640096; PMCID: PMC4325563.
Baker JC, Demertzis JL, Rhodes NG, Wessell DE, Rubin DA. Diabetic musculoskeletal complications and their imaging mimics. Radiographics 2012;32(7):1959–74. C
Khodaee M, Lombardo D, Montgomery LC, Lyon C, Mon-toya C. Clinical inquiry: what’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? J Fam Pract 2015;64(5):309–310, 321
Yansouni CP, Mak A, Libman MD. Limitations of magnetic resonance imaging in the diagnosis of osteomyelitis underlying diabetic foot ulcers. Clin Infect Dis 2009;48(1):135
Abdel Razek AAK, Samir S. Diagnostic performance of diffusion-weighted MR imaging in differentiation of diabetic osteoarthropathy and osteomyelitis in diabetic foot. Eur J Radiol. 2017 Apr;89:221-225. doi: 10.1016/j.ejrad.2017.02.015. Epub 2017 Feb 14. PMID: 28267543.
Guerini H, Omoumi P, Guichoux F, et al. Fat Suppression with Dixon Techniques in Musculoskeletal Magnetic Resonance Imaging: A Pictorial Review. Semin Musculoskelet Radiol. 2015;19(4):335-347. doi:10.1055/s-0035-1565913
Lavini C, Buiter MS, Maas M. Use of dynamic contrast enhanced time intensity curve shape analysis in MRI: theory and practice. Rep Med Imaging 2013;6(1):71–82
Assaad-Khalil S, Zaki A, Abdel Rehim A et al. (2015): Prevalence of diabetic foot disorders and related risk factors among Egyptian subjects with diabetes. Prim Care Diabetes, 9(4):297–303
Gouveri E, Papanas N. Charcot osteoarthropathy in diabetes: a brief review with an emphasis on clinical practice. World J Diabetes 2011;2: 59e65.
Menke J, Larsen J. Meta-analysis: accuracy of contrast-enhanced magnetic resonance angiography for assessing steno-occlusions in peripheral arterial disease. Ann Intern Med 2010; 153(5): 325–334.
Troisi N, Turini F, Chisci E, et al. Impact of Pedal Arch Patency on Tissue Loss and Time to Healing in Diabetic Patients with Foot Wounds Undergoing Infrainguinal Endovascular Revascularization. Korean J Radiol. 2018;19(1):47-53. doi:10.3348/kjr.2018.19.1.47