Pelvik Organ Prolapsusu (POP)
Özet
Pelvik organ prolapsusu (POP); kas, ligaman ve fasyanın zayıflamasıyla pelvik organların sarkması sonucu gelişen, kadınlarda yaygın bir ürojinekolojik sorundur. Yaşlanma, ırk, menopoz, vajinal doğum, obezite, konstipasyon ve sigara gibi modifiye edilebilen veya edilemeyen birçok risk faktörü etyolojide rol oynar. POP-Q sistemiyle evrelendirilen bu durum; pelvik dolgunluk, idrar ve dışkılama disfonksiyonu ile cinsel rahatsızlıklara yol açarak yaşam kalitesini olumsuz etkiler. Tedavide hafif vakalarda gözlem, kilo kontrolü ve lifli diyet gibi yaşam tarzı değişiklikleri önerilir. Konservatif yöntemler arasında pelvik taban kas egzersizleri (PTKE/Kegel), elektrik ve vibrasyon stimülasyonları ile mekanik destek sağlayan pesser kullanımı yer alır. İleri derece veya semptomatik olgularda ise hastanın fertilite beklentisine ve cinsel hayatına göre cerrahi tedavi planlanır. Cerrahi seçenekler arasında fertilite arzusu olmayanlarda vajinal histerektomi, vajinal kafın kısaltıldığı kolpoklezis ve apikal destek sağlayan sakrospinöz fiksasyon, iliokoksigeus, uterosakral veya abdominal sakrokolpopeksi gibi süspansiyon prosedürleri bulunur. Her cerrahi işlemin enfeksiyon, kanama ve vajinal kısalma gibi komplikasyon riskleri mevcut olup öncelikle invaziv olmayan yöntemler denenmelidir.
Pelvic organ prolapse (POP) is a common urogynecological problem in women that develops as a result of the prolapse of pelvic organs due to the weakening of muscles, ligaments, and fascia. Many modifiable or non-modifiable risk factors, such as aging, race, menopause, vaginal delivery, obesity, constipation, and smoking, play a role in its etiology. This condition, staged with the POP-Q system, negatively affects the quality of life by causing pelvic fullness, urinary and defecation dysfunction, and sexual discomfort. In treatment, observation and lifestyle changes such as weight control and a high-fiber diet are recommended for mild cases. Conservative methods include pelvic floor muscle training (PFMT/Kegel), electrical and vibratory stimulations, and the use of pessaries providing mechanical support. In advanced or symptomatic cases, surgical treatment is planned according to the patient's fertility expectations and sexual life. Surgical options include vaginal hysterectomy for those without fertility desire, colpocleisis where the vaginal cuff is shortened, and suspension procedures providing apical support such as sacrospinous fixation, iliococcygeus, uterosacral, or abdominal sacrocolpopexy. Every surgical procedure carries risks of complications such as infection, bleeding, and vaginal shortening, and non-invasive methods should be tried first.
Referanslar
Khan ZA, Whittal C, Mansol S, Osborne LA, Reed P, Emery S. Effect of depression and anxiety on the success of pelvic floor muscle training for pelvic floor dysfunction. J Obstet Gynaecol. 2013;33(7):710-4. doi: 10.3109/01443615.2013.813913.
Zhang FW, Wei F, Wang HL, Pan YQ, Zhen JY, Zhang JX, Yang KH. Does pelvic floor muscle training augment the effect of surgery in women with pelvic organ prolapse? A systematic review of randomized controlled trials. Neurourol Urodyn. 2016;35(6):666-74. doi: 10.1002/nau.22784.
Yan W, Li X, Sun S, Xiang Y, Zhou Y, Zeng X, Xie F, Jiang H, Liu Q, Xiang J. Risk factors for female pelvic organ prolapse and urinary incontinence. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(12):1345-1350. Chinese. doi: 10.11817/j.issn.1672-7347.2018.12.010.
Gill EJ, Hurt WG. Pathophysiology of pelvic organ prolapse. Obstet Gynecol Clin North Am. 1998;25(4):757-69. doi: 10.1016/s0889-8545(05)70041-3.
DeLancey JO. What's new in the functional anatomy of pelvic organ prolapse? Curr Opin Obstet Gynecol. 2016;28(5):420-9. doi: 10.1097/GCO.0000000000000312.
Rogo-Gupta L. Current trends in surgical repair of pelvic organ prolapse. Curr Opin Obstet Gynecol. 2013;25(5):395-8. doi: 10.1097/GCO.0b013e3283648cfb.
Chow D, Rodríguez LV. Epidemiology and prevalence of pelvic organ prolapse. Curr Opin Urol. 2013;23(4):293-8. doi: 10.1097/MOU.0b013e3283619ed0.
Kudish BI, Iglesia CB, Gutman RE, Sokol AI, Rodgers AK, Gass M, O'Sullivan MJ, Larson J, Abu-Sitta M, Howard BV. Risk factors for prolapse development in white, black, and Hispanic women. Female Pelvic Med Reconstr Surg. 2011;17(2):80-90. doi: 10.1097/SPV.0b013e31820e5d06.
Bump RC, Mattiasson A, Bø K, Brubaker LP, DeLancey JO, Klarskov P, Shull BL, Smith AR. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 1996;175(1):10-7. doi: 10.1016/s0002-9378(96)70243-0.
Kapoor DS, Thakar R, Sultan AH, Oliver R. Conservative versus surgical management of prolapse: what dictates patient choice? Int Urogynecol J Pelvic Floor Dysfunct. 2009;20(10):1157-61. doi: 10.1007/s00192-009-0930-x.
Coolen AWM, Troost S, Mol BWJ, Roovers JPWR, Bongers MY. Primary treatment of pelvic organ prolapse: pessary use versus prolapse surgery. Int Urogynecol J. 2018;29(1):99-107. doi: 10.1007/s00192-017-3372-x.
Manonai J, Sarit-Apirak S, Udomsubpayakul U. Vaginal ring pessary use for pelvic organ prolapse: continuation rates and predictors of continued use. Menopause. 2018;26(6):665-669. doi: 10.1097/GME.0000000000001277.
Li C, Gong Y, Wang B. The efficacy of pelvic floor muscle training for pelvic organ prolapse: a systematic review and meta-analysis. Int Urogynecol J. 2016;27(7):981-92. doi: 10.1007/s00192-015-2846-y.
Rodrigues MP, Barbosa LJF, Paiva LL, Mallmann S, Sanches PRS, Ferreira CF, Ramos JGL. Effect of intravaginal vibratory versus electric stimulation on the pelvic floor muscles: A randomized clinical trial. Eur J Obstet Gynecol Reprod Biol X. 2019;3:100022. doi: 10.1016/j.eurox.2019.100022.
Allon EF. The role of neuromuscular electrical stimulation in the rehabilitation of the pelvic floor muscles. Br J Nurs. 2019;28(15):968-974. doi: 10.12968/bjon.2019.28.15.968.
Zhong F, Miao W, Yu Z, Hong L, Deng N. Clinical effect of electrical stimulation biofeedback therapy combined with pelvic floor functional exercise on postpartum pelvic organ prolapse. Am J Transl Res. 2021;13(6):6629-6637.
Jelovsek JE, Barber MD, Brubaker L, Norton P, Gantz M, Richter HE, Weidner A, Menefee S, Schaffer J, Pugh N, Meikle S; NICHD Pelvic Floor Disorders Network. Effect of Uterosacral Ligament Suspension vs Sacrospinous Ligament Fixation With or Without Perioperative Behavioral Therapy for Pelvic Organ Vaginal Prolapse on Surgical Outcomes and Prolapse Symptoms at 5 Years in the OPTIMAL Randomized Clinical Trial. JAMA. 2018 Apr 17;319(15):1554-1565. doi: 10.1001/jama.2018.2827.
Deffieux X, Thubert T, Donon L, Hermieu JF, Le Normand L, Trichot C. Chirurgie d'occlusion vaginale (colpocléisis) pour prolapsus génital : recommandations pour la pratique clinique [Colpocleisis: guidelines for clinical practice]. Prog Urol. 2016;26(1):61-72. French. doi: 10.1016/S1166-7087(16)30429-8.
Declas E, Giraudet G, Delplanque S, Rubod C, Cosson M. How we perform a posterior sacrospinous ligament fixation by the vaginal route. Int Urogynecol J. 2020;31(7):1479-1481. doi: 10.1007/s00192-019-04149-8.
Pahwa AK, Arya LA, Andy UU. Management of arterial and venous hemorrhage during sacrospinous ligament fixation: cases and review of the literature. Int Urogynecol J. 2016;27(3):387-91. doi: 10.1007/s00192-015-2818-2.
Meeks GR, Washburne JF, McGehee RP, Wiser WL. Repair of vaginal vault prolapse by suspension of the vagina to iliococcygeus (prespinous) fascia. Am J Obstet Gynecol. 1994;171(6):1444-52; discussion 1452-4. doi: 10.1016/0002-9378(94)90386-7.
Wu PJ, Tseng LH, Chang SD, Lee CL. Clinical outcome after laparoscopic assisted vaginal hysterectomy with transvaginal uterosacral ligament fixation. Taiwan J Obstet Gynecol. 2012;51(3):363-7. doi: 10.1016/j.tjog.2012.07.008.
Aronson MP, Aronson PK, Howard AE, Morse AN, Baker SP, Young SB. Low risk of ureteral obstruction with "deep" (dorsal/posterior) uterosacral ligament suture placement for transvaginal apical suspension. Am J Obstet Gynecol. 2005;192(5):1530-6. doi: 10.1016/j.ajog.2004.10.608.
Geltzeiler CB, Birnbaum EH, Silviera ML, Mutch MG, Vetter J, Wise PE, Hunt SR, Glasgow SC. Combined rectopexy and sacrocolpopexy is safe for correction of pelvic organ prolapse. Int J Colorectal Dis. 2018;33(10):1453-1459. doi: 10.1007/s00384-018-3140-5.