Temporomandibular Eklem Bozuklukları ve Ruhsal Durumlarla İlişkisi
Özet
Temporomandibular bozukluklar (TMB), çiğneme kaslarını, temporomandibular eklemi (TME) ve ilişkili dokuları etkileyen, toplumda yaygın görülen kas-iskelet sistemi rahatsızlıklarıdır. En sık klinik belirtisi ağrı olan bu bozukluklar, kadınlarda erkeklere oranla daha sık gözlenmektedir. TMB'nin multifaktöriyel etiyolojisinde nöromusküler ve nörobiyolojik etkenlerin yanı sıra biyopsikososyal faktörler de kritik bir rol oynamaktadır. Araştırmalar; anksiyete, depresyon, somatizasyon, uyku bozuklukları, bruksizm ve bazı kişilik özelliklerinin TMB gelişimi, kronikleşmesi ve tedavi süreçleriyle doğrudan ilişkili olduğunu göstermektedir. Özellikle kas kaynaklı bozukluğu (miyalji) olan hastalarda psikososyal zorlanma düzeyi, eklem sorunu (artralji) olanlara kıyasla daha belirgindir. Şizofreni gibi ciddi psikotik bozukluklarda ise hem emosyonel stres hem de antipsikotik ilaçların yan etkileri TMB riskini artırmaktadır. Hastalığın yönetiminde standart bir yaklaşım sağlamak adına iki eksenli bir sınıflandırma şeması (Eksen I: klinik karakterler, Eksen II: biyopsikososyal durum) kullanılmaktadır. TMB'nin karmaşık doğası, teşhis ve tedavide bütüncül bir yaklaşımı zorunlu kılmaktadır. Tedavi süreci genellikle cerrahi olmayan konservatif yöntemlerle başlar; ilaç tedavisi ve splint uygulamalarının yanı sıra Bilişsel Davranışçı Terapi (BDT), Kabul ve Kararlılık Terapisi (ACT) ile şefkat odaklı psikoterapileri içeren multidisipliner yaklaşımlar tedavinin başarısını ve hastaların yaşam kalitesini önemli ölçüde artırmaktadır.
Temporomandibular disorders (TMD) are common musculoskeletal conditions affecting the masticatory muscles, the temporomandibular joint (TMJ), and associated tissues, with pain being the most frequent clinical symptom and a higher prevalence observed in women than men. In the multifactorial etiology of TMD, biopsychosocial factors play a critical role alongside neuromuscular and neurobiological elements, as research demonstrates that anxiety, depression, somatization, sleep disorders, bruxism, and specific personality traits are directly linked to the development, chronicity, and treatment outcomes of the disorder. Psychosocial distress is particularly more pronounced in patients with muscle-related disorders (myalgia) compared to those with joint-related issues (arthralgia), while severe psychotic disorders like schizophrenia further elevate TMD risks due to emotional stress and the side effects of antipsychotic medications. To ensure a standardized clinical approach, a dual-axis classification system is utilized, where Axis I evaluates clinical characteristics and Axis II addresses biopsychosocial factors. Consequently, the complex nature of TMD necessitates a holistic approach in diagnosis and management; treatment typically initiates with non-surgical conservative methods, and multidisciplinary approaches integrating pharmacotherapy and splints with psychotherapies—such as Cognitive Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT), and compassion-focused therapy—significantly enhance treatment success and patient quality of life.
Referanslar
Buescher JJ. Temporpmandibular Joint Disorders. American Family Physician, 2007; 76(10): 1477-1482
Li DTS, Leung YY. Temporomandibular Disorders: Current Concepts and Controversies in Diagnosis and Management. Diagnostics, 2021; 11: 459. https://doi.org/10.3390/diagnostics11030459
Manfredini D, Bandettini Di Poggio A, Cantini E, et al. Mood and Anxiety Psychopathology and Temporomandibular Disorder: A Spectrum Approach. Journal of Oral Rehabilitation, 2004; 31:933-940
Dworkin FS, Massoth DL. Temporomandibular disorders and chronic pain: Disease or İllness? The Journal of Prosthetic Dentistry, 1994; 72(1): 29-38
Penlington C, Otemade AA, Bowes C, et al. Psychological therapies for temporomandibular disorders (TMD). Cochrane Database of Systematic Reviews 2019; Issue 12. Art. No.: CD013515. DOI: 10.1002/14651858.CD013515.
Geniş B, Hocaoğlu Ç. Temporomandibular Bozukluklar ve Bruksizmde Eşlik Eden Psikiyatrik Bozukluklar ve Tedavi Seçenekleri. Psikiyatride Güncel Yaklaşımlar, 2020; 12(2):205-231 doi: 10.18863/pgy.570861
Meldolesi GN, Picardi A, Accivile E, et al. Personality and Psychopathology in Patients with Temporomandibular Joint Pain-Dysfunction Syndrome. Psyhother Psyhosom, 2000; 69:322-328
Yap AU, Tan KBC, Chua EK, et al. Depression and Somatization in Patients with Temporomandibular Disorders. The Journal of Prosthetic Dentistry, 2002, 88(5): 479-484
Kindler S, Schwahn C, Terock J, et al. Alexithymia and Temporomandibular Joint and Facial Pain in the General Population. J Oral Rehabil, 2018;1–11. Doi: 10.1111/joor.12748
Yap AU, Cao Y, Zhang MJ, et al. Comparison of Emotional Disturbance, Sleep and Life Quality in Adult Patients with Temporomandibular Disorders of Different Origins. Clin Oral Investig, 2021; 25(6): 4097-4105 doi: 10.1007/s00784-020-03740-4.
Filingim RB, Ohrbach R, Greenspan JD, et al. Psychological factors associated with development of TMD: the OPPERA prospective cohort study. Journal of Pain, 2013;14(12 Suppl):T75-90. doi: 10.1016/j.jpain.2013.06.009.
Nifosi F, Violata E, Pavan C, et al. Psychopathology And Clinical Features In An Italian Sample Of Patients With Myofascial And Temporomandibular Joint Pain: Preliminary Data. Int’l. J. Psychiatry In Medicine, 2007; 37(3): 283-300. doi: 10.2190/PM.37.3.f
Manfredini D, Marini M, Pavan C, et al. Psychosocial profiles of painful TMD patients. Journal of Oral Rehabilitation, 2009; 36: 193–198. doi: 10.1111/j.1365-2842.2008.01926.x
Mingarelli A, Casagrande M, Pirchio RD, et al. Alexithymia partly predicts pain, poor health and social difficulties in patients with temporomandibular disorders. Journal of Oral Rehabilitation, 2013; 40: 723-730. doi: 10.1111/joor.12084
Nguyen MS, Reemann P, Loorits D, et al. Association of Temporomandibular Joint Osseous Changes with Anxiety, Depression, and Limitation of Mandibular Function in Elderly Vietnamese. East Asian Arch Psychiatry 2019; 29:20-5 DOI: 10.12809/eaap1749
Slade GD, Diatchenko L, Bhalang K, et al. Influence of Psychological Factors on Risk of Temporomandibular Disorders. J Dent Res, 2007; 86(11):1120-1125
Aggarwal VR, Macfarlane GJ, Farragher TM, et al. Risk factors for onset of chronic oro-facial pain – Results of the North Cheshire oro-facial pain prospective population study. Pain, 2010; 149: 354–359. doi:10.1016/j.pain.2010.02.040
Kindler S, Samietz S, Houshmand M, et al. Depressive and Anxiety Symptoms as Risk Factors for Temporomandibular Joint Pain: A Prospective Cohort Study in the General Population. The Journal of Pain, 2012; 13(12): 1188-1197. http://dx.doi.org/10.1016/j.jpain.2012.09.004
Dougall AL, Jimenez CA, Haggard RA, et al. Biopsychosocial Factors Associated With The Subcategories Of Acute Temporomandibular Joint Disorders. J Orofac Pain., 2012; 26(1): 7–16.
Smith MT, Wickwire EM, Grace EG, et al. Sleep Disorders and their Association with Laboratory Pain Sensitivity in Temporomandibular Joint Disorder. Sleep, 2009; 32(6): 779-790
Smardz J, Martynowicz H, Wojakowska A, et al. Correlation between Sleep Bruxism, Stress,and Depression—A Polysomnographic Study. J. Clin. Med., 2019; 8: 1344. doi:10.3390/jcm8091344
Mısırlıoğlu M, Adışen MZ, Yılmaz S. Bruksizmin tanısı, tedavisi ve görüntülenmesi üzerine yeni görüşler. A.Ü. Diş Hek. Fak. Derg., 2012;39(2): 93-102.
Nascimento A, Sena EP, Baptista AP. Temporomandibular disorders in patients with schizophrenia using antipsychotic agents: a discussion paper. Drug, Healthcare and Patient Safety 2014;6: 21–27
Ingawale S, Goswami T. Temporomandibular Joint: Disorders, Treatments, And Biomechanics Annals Of Biomedical Engineering. 2009;37(5):976–996 DOI: 10.1007/S10439-009-9659-4.
Gil-Martinez A, Paris-Alemany A, Lopez-de-Uralde-Villanueva I, et al. Management of pain in patients with temporomandibular disorder (TMD): challenges and solutions. Journal of Pain Research, 2018;11: 571–587.