Sepsis Tanısındaki Yenilikler

Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287

Rhee C, Dantes R, Epstein L, et al. Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. JAMA. 2017;318(13):1241-1249. doi:10.1001/jama.2017.13836

Da Rin G, Zoppelletto M, Lippi G. Integration of Diagnostic Microbiology in a Model of Total Laboratory Automation. Lab Med. 2016;47(1):73-82. doi:10.1093/labmed/lmv007

Egi M, Ogura H, Yatabe T, et al. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020). J Intensive Care. 2021;9(1):53. Published 2021 Aug 25. doi:10.1186/s40560-021-00555-7

Briggs N, Campbell S, Gupta S. Advances in rapid diagnostics for bloodstream infections. Diagn Microbiol Infect Dis. 2021;99(1):115219. doi:10.1016/j.diagmicrobio.2020.115219

Duncan CF, Youngstein T, Kirrane MD, et al. Diagnostic Challenges in Sepsis. Curr Infect Dis Rep. 2021;23(12):22. doi:10.1007/s11908-021-00765-y

Zhong H, Wu ML, Feng WJ, et al. Accuracy and applicability of different phenotypic methods for carbapenemase detection in Enterobacteriaceae: A systematic review and meta-analysis. J Glob Antimicrob Resist. 2020;21:138-147. doi:10.1016/j.jgar.2019.10.010

Huang YL, Sun QL, Li JP, et al. Evaluation of an in-house MALDI-TOF MS rapid diagnostic method for direct identification of micro-organisms from blood cultures. J Med Microbiol. 2019;68(1):41-47. doi:10.1099/jmm.0.000866

Wu S, Xu J, Qiu C, et al. Direct antimicrobial susceptibility tests of bacteria and yeasts from positive blood cultures by using serum separator gel tubes and MALDI-TOF MS. J Microbiol Methods. 2019;157:16-20. doi:10.1016/j.mimet.2018.12.011

Cherkaoui A, Renzi G, Azam N, et al. Rapid identification by MALDI-TOF/MS and antimicrobial disk diffusion susceptibility testing for positive blood cultures after a short incubation on the WASPLab. Eur J Clin Microbiol Infect Dis. 2020;39(6):1063-1070. doi:10.1007/s10096-020-03817-8

Makristathis A, Harrison N, Ratzinger F, et al. Substantial diagnostic impact of blood culture independent molecular methods in bloodstream infections: Superior performance of PCR/ESI-MS. Sci Rep. 2018;8(1):16024. Published 2018 Oct 30. doi:10.1038/s41598-018-34298-7

Mustafa MI, Al-Marzooq F, How SH, et al. The use of multiplex real-time PCR improves the detection of the bacterial etiology of community acquired pneumonia. Trop Biomed. 2011;28(3):531-544.

Choudhary ML, Anand SP, Tikhe SA, et al. Comparison of the conventional multiplex RT-PCR, real time RT-PCR and Luminex xTAG® RVP fast assay for the detection of respiratory viruses. J Med Virol. 2016;88(1):51-57. doi:10.1002/jmv.24299

Navarro E, Serrano-Heras G, Castaño MJ, et al. Real-time PCR detection chemistry. Clin Chim Acta. 2015;439:231-250. doi:10.1016/j.cca.2014.10.017

Sinha M, Jupe J, Mack H, et al. Emerging Technologies for Molecular Diagnosis of Sepsis. Clin Microbiol Rev. 2018;31(2):e00089-17. Published 2018 Feb 28. doi:10.1128/CMR.00089-17

Desmet S, Maertens J, Bueselinck K, et al. Broad-Range PCR Coupled with Electrospray Ionization Time of Flight Mass Spectrometry for Detection of Bacteremia and Fungemia in Patients with Neutropenic Fever. J Clin Microbiol. 2016;54(10):2513-2520. doi:10.1128/JCM.01066-16

Opota O, Jaton K, Greub G. Microbial diagnosis of bloodstream infection: towards molecular diagnosis directly from blood. Clin Microbiol Infect. 2015;21(4):323-331. doi:10.1016/j.cmi.2015.02.005

Dark P, Blackwood B, Gates S, et al. Accuracy of LightCycler(®) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis. Intensive Care Med. 2015;41(1):21-33. doi:10.1007/s00134-014-3553-8

Chang SS, Hsieh WH, Liu TS, et al. Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis - a systemic review and meta-analysis. PLoS One. 2013;8(5):e62323. Published 2013 May 29. doi:10.1371/journal.pone.0062323

Horz HP, Scheer S, Vianna ME, Conrads G. New methods for selective isolation of bacterial DNA from human clinical specimens. Anaerobe. 2010;16(1):47-53. doi:10.1016/j.anaerobe.2009.04.009

Leitner E, Kessler HH, Spindelboeck W, et al. Comparison of two molecular assays with conventional blood culture for diagnosis of sepsis. J Microbiol Methods. 2013;92(3):253-255. doi:10.1016/j.mimet.2012.12.012

Quick J, Ashton P, Calus S, et al. Rapid draft sequencing and real-time nanopore sequencing in a hospital outbreak of Salmonella. Genome Biol. 2015;16:114. Published 2015 May 30. doi:10.1186/s13059-015-0677-2

Velez DO, Mack H, Jupe J, et al. Massively parallel digital high resolution melt for rapid and absolutely quantitative sequence profiling. Sci Rep. 2017;7:42326. Published 2017 Feb 8. doi:10.1038/srep42326

Miller R, Lopansri B, McHugh L, et al. Validation of a novel host response assay to distinguish SIRS and sepsis in critically ill patients. Crit Care Med 2015;43:252. https://doi.org/10.1097/ 01.ccm.0000474833.48035.b5.

Miller RR 3rd, Lopansri BK, Burke JP, et al. Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU [published correction appears in Am J Respir Crit Care Med. 2020 Jul 1;202(1):155]. Am J Respir Crit Care Med. 2018;198(7):903-913. doi:10.1164/rccm.201712-2472OC

Kang DK, Ali MM, Zhang K, et al. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun. 2014;5:5427. Published 2014 Nov 13. doi:10.1038/ncomms6427

Blauwkamp TA, Thair S, Rosen MJ, et al. Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease. Nat Microbiol. 2019;4(4):663-674. doi:10.1038/s41564-018-0349-6

Han D, Li R, Shi J, Tan P, Zhang R, Li J. Liquid biopsy for infectious diseases: a focus on microbial cell-free DNA sequencing. Theranostics. 2020;10(12):5501-5513. Published 2020 Apr 7. doi:10.7150/thno.45554

Eichenberger EM, de Vries CR, Ruffin F, et al. Microbial Cell-Free DNA Identifies Etiology of Bloodstream Infections, Persists Longer Than Conventional Blood Cultures, and Its Duration of Detection Is Associated With Metastatic Infection in Patients With Staphylococcus aureus and Gram-Negative Bacteremia. Clin Infect Dis. 2022;74(11):2020-2027. doi:10.1093/cid/ciab742

Mayhew MB, Buturovic L, Luethy R, et al. A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections. Nat Commun. 2020;11(1):1177. Published 2020 Mar 4. doi:10.1038/s41467-020-14975-w

Atallah J, Mansour MK. Implications of Using Host Response-Based Molecular Diagnostics on the Management of Bacterial and Viral Infections: A Review. Front Med (Lausanne). 2022;9:805107. Published 2022 Feb 3. doi:10.3389/fmed.2022.805107

Bauer W, Kappert K, Galtung N, et al. A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study. Crit Care Med. 2021;49(10):1664-1673. doi:10.1097/CCM.0000000000005119

Leong K, Gaglani B, Khanna AK, McCurdy MT. Novel Diagnostics and Therapeutics in Sepsis. Biomedicines. 2021;9(3):311. Published 2021 Mar 18. doi:10.3390/biomedicines9030311

Larsson A, Tydén J, Johansson J, et al. Calprotectin is superior to procalcitonin as a sepsis marker and predictor of 30-day mortality in intensive care patients. Scand J Clin Lab Invest. 2020;80(2):156-161. doi:10.1080/00365513.2019.1703216

Gao RY, Jia HM, Han YZ, et al. Calprotectin as a diagnostic marker for sepsis: A meta-analysis. Front Cell Infect Microbiol. 2022;12:1045636. Published 2022 Nov 28. doi:10.3389/fcimb.2022.1045636

Ma L, Zhang H, Yin YL, et al. Role of interleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndrome. Cytokine. 2016;88:126-135. doi:10.1016/j.cyto.2016.08.033

Molano Franco D, Arevalo-Rodriguez I, Roqué I Figuls M, et al. Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults. Cochrane Database Syst Rev. 2019;4(4):CD011811. Published 2019 Apr 30. doi:10.1002/14651858.CD011811.pub2

Huang Q, Xiong H, Yan P, et al. The Diagnostic and Prognostic Value of suPAR in Patients with Sepsis: A Systematic Review and Meta-Analysis. Shock. 2020;53(4):416-425. doi:10.1097/SHK.0000000000001434

Petersen JEV, Kallemose T, Barton KD, et al. Soluble urokinase plasminogen activator receptor (suPAR) as a prognostic marker of mortality in healthy, general and patient populations: protocol for a systematic review and meta-analysis. BMJ Open. 2020;10(7):e036125. Published 2020 Jul 19. doi:10.1136/bmjopen-2019-036125

Chen M, Yuan J, Yang Z, et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019;31(10):1224-1230. doi:10.3760/cma.j.issn.2095-4352.2019.10.009

Wu YL, Yo CH, Hsu WT, et al. Accuracy of Heparin-Binding Protein in Diagnosing Sepsis: A Systematic Review and Meta-Analysis. Crit Care Med. 2021;49(1):e80-e90. doi:10.1097/CCM.0000000000004738

Kondo Y, Umemura Y, Hayashida K, et al. Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: a systematic review and meta-analysis. J Intensive Care. 2019;7:22. Published 2019 Apr 15. doi:10.1186/s40560-019-0374-4

Yoon SH, Kim EH, Kim HY, et al. Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis. BMC Infect Dis. 2019;19(1):760. Published 2019 Aug 30. doi:10.1186/s12879-019-4397-1

Yeh CF, Wu CC, Liu SH, et al. Comparison of the accuracy of neutrophil CD64, procalcitonin, and C-reactive protein for sepsis identification: a systematic review and meta-analysis. Ann Intensive Care. 2019;9(1):5. Published 2019 Jan 8. doi:10.1186/s13613-018-0479-2

Cong S, Ma T, Di X, et al. Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis. BMC Infect Dis. 2021;21(1):384. Published 2021 Apr 26. doi:10.1186/s12879-021-06064-0

Chang W, Peng F, Meng SS, et al. Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis. BMC Immunol. 2020;21(1):2. Published 2020 Jan 13. doi:10.1186/s12865-020-0332-x

Koyama T, Kuriyama N, Suzuki Y, et al. Author Correction: Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study. Sci Rep. 2021;11(1):17638. Published 2021 Aug 30. doi:10.1038/s41598-021-96984-3

Li P, Wang C, Pang S. The diagnostic accuracy of mid-regional pro-adrenomedullin for sepsis: a systematic review and meta-analysis. Minerva Anestesiol. 2021;87(10):1117-1127. doi:10.23736/S0375-9393.21.15585-3

Shen X, Zhang J, Huang Y, et al. Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis. J Intensive Care. 2020;8(1):84. Published 2020 Nov 2. doi:10.1186/s40560-020-00497-6

Zhao J, Wang Q, Zhu R, et al. Circulating Non-coding RNAs as Potential Biomarkers for Ischemic Stroke: A Systematic Review. J Mol Neurosci. 2022;72(8):1572-1585. doi:10.1007/s12031-022-01991-2