Approach to the Adult With Dyspepsia

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Hammer J, Führer M, Pipal L, Matiasek J. Hypersensitivity for capsaicin in patients with functional dyspepsia. Neurogastroenterol Motil. 2008;20(2):125-33.

van Boxel OS, ter Linde JJ, Siersema PD, Smout AJ. Role of chemical stimulation of the duodenum in dyspeptic symptom generation. Am J Gastroenterol. 2010;105(4):803-11; quiz 2, 12.

Cheung C, Lan L, Kyaw M, Mak A, Chan A, Chan Y, et al. Up‐regulation of transient receptor potential vanilloid (TRPV) and down‐regulation of brain‐derived neurotrophic factor (BDNF) expression in patients with functional dyspepsia (FD). Neurogastroenterology & Motility. 2018;30(2):e13176.

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Nakae H, Tsuda A, Matsuoka T, Mine T, Koga Y. Gastric microbiota in the functional dyspepsia patients treated with probiotic yogurt. BMJ Open Gastroenterology. 2016;3(1):e000109.

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Chen Y, Wang R, Hou B, Feng F, Fang X, Zhu L, et al. Regional Brain Activity During Rest and Gastric Water Load in Subtypes of Functional Dyspepsia: A Preliminary Brain Functional Magnetic Resonance Imaging Study. J Neurogastroenterol Motil. 2018;24(2):268-79.

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Liebregts T, Adam B, Bredack C, Gururatsakul M, Pilkington KR, Brierley SM, et al. Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. Am J Gastroenterol. 2011;106(6):1089-98.

Talley NJ, Walker MM, Aro P, Ronkainen J, Storskrubb T, Hindley LA, et al. Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study. Clin Gastroenterol Hepatol. 2007;5(10):1175-83.

Vanheel H, Vicario M, Boesmans W, Vanuytsel T, Salvo-Romero E, Tack J, et al. Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation. Sci Rep. 2018;8(1):5383.

Du L, Shen J, Kim JJ, Yu Y, Ma L, Dai N. Increased Duodenal Eosinophil Degranulation in Patients with Functional Dyspepsia: A Prospective Study. Sci Rep. 2016;6:34305.

Cirillo C, Bessissow T, Desmet AS, Vanheel H, Tack J, Vanden Berghe P. Evidence for neuronal and structural changes in submucous ganglia of patients with functional dyspepsia. Am J Gastroenterol. 2015;110(8):1205-15.

Wauters L, Ceulemans M, Frings D, Lambaerts M, Accarie A, Toth J, et al. Proton Pump Inhibitors Reduce Duodenal Eosinophilia, Mast Cells, and Permeability in Patients With Functional Dyspepsia. Gastroenterology. 2021;160(5):1521-31.e9.

Tack J, Schol J, Van den Houte K, Huang IH, Carbone F. Paradigm Shift: Functional Dyspepsia-A "Leaky Gut" Disorder? Am J Gastroenterol. 2021;116(2):274-5.

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Lacy BE. Functional dyspepsia and gastroparesis: one disease or two? Am J Gastroenterol. 2012;107(11):1615-20.

Stanghellini V, Tack J. Gastroparesis: separate entity or just a part of dyspepsia? Gut. 2014;63(12):1972-8.