Solunum Merkezleri’nin Santral Sinir Sistemi Tarafından Kontrolü ve Prebötzinger Kompleksi

Culver BH. Physiology. Albert RK, Spiro SG, Jett JR. Comprehensive Respiratory Medicine. London Mosby 1999;27-29.

Bolton CF, Chen R, Wigdiks EFM, Zifko UA. Anatomy and physiology of the nervous system, control of respiration. In: Neurology of Breathing. United States of America, 2004;2 19-35.

Haji A, Takeda R, Okazaki M. Neuropharmacology of control of respiratory rhythm and pattern in mature mammals. Pharmacology and Therapeutic 2000;86:277-304

Martini FH. The Respiratory System In: Martini FH, ed. Fundamentals of Anatomy&Physiology, 5th edition New Jersey, Prentice. Hall 2001;23:797-844.

Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science. 1991;254:726–9.

Anderson, TM., Garcia, AJ. 3rd, Baertsch, NA., Pollak, J., Bloom, JC., Wei, AD., Rai, KG. and Ramirez, JM. (2016) A novel excitatory network for the control of breathing. Nature 536, 76-80.

Flourens M. Nouveau details sur le noeud vital. Compt Rend Acad Sci. 1858;47:803–6.

Lumsden T. The regulation of respiration: Part I. J Physiol. 1923;58:81–91.

St John WM. Noeud vital for breathing in the brainstem: gasping–yes, eupnoea–doubtful. Philos Trans R Soc Lond B Biol Sci. 2009;364:2625–33.

Lieske SP, Thoby-Brisson M, Telgkamp P, Ramirez JM. Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps [see comment] Nat Neurosci. 2000;3:600–7

Peña F, Parkis MA, Tryba AK, Ramirez JM. Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia. Neuron. 2004;43:105–17

Ramirez JM, Schwarzacher SW, Pierrefiche O, Olivera BM, Richter DW. Selective lesioning of the cat pre-Bötzinger complex in vivo eliminates breathing but not gasping. J Physiol. 1998;507:895–907.

Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL. Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci. 2008;11:538–40.

Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, et al. Hindbrain interneurons and axon guidance signaling critical for breathing. Nat Neurosci. 2010;13:1066–74.

Gray PA, Hayes JA, Ling GY, Llona I, Tupal S, Picardo MC, et al. Developmental origin of PreBotzinger complex respiratory neurons. J Neurosci. 2010;30:14883–95.

Ramirez JM. The human pre-Bötzinger complex identified. Brain. 2011 Jan;134(Pt 1):8-10. doi: 10.1093/brain/awq357

Morgado-Valle, C. and Beltran-Parrazal, L. (2017) Respiratory rhythm generation: the whole is greater than the sum of the parts. Advances in Experimental Medicine and Biology 1015, 147-161.

Ezure, K. and Manabe, M. (1988) Decrementing expiratory neurons of the Bötzinger complex. Experimental Brain Research 72 159-166.

Ghali, MGZ. (2017c) The bulbospinal network controlling the phrenic motor system: laterality and course of descending projections. Neuroscience Research 121, 7-17.

Jiang, C. and Lipski, J. (1990) Extensive monosynaptic inhibition of ventral respiratory group neurons by augmenting neurons in the Bötzinger complex in the cat. Experimental Brain Research 81, 639-648.

Yang, CF. and Feldman, JL. (2018) Efferent projections of excitatory and inhibitory preBötzinger Complex neurons. Journal of Comparative Neurology 526, 1389-1402.

Ezure, K., Tanaka, I. and Kondo, M. (2003) Glycine is used as a transmitter by decrementing expiratory neurons of the ventrolateral medulla in the rat. Journal of Neuroscience 23, 8941-8948.

Molkov, YI., Rubin, JE., Rybak, IA. and Smith, JC. (2017) Computational models of the neural control of breathing. Wiley Interdisciplinary Reviews. Systems Biology and Medicine 9.

Horn, EM. and Waldrop, TG. (1997) Oxygen-sensing neurons in the caudal hypothalamus and their role in cardiorespiratory control. Respiratory Physiology 110, 219-228.

Ghali, MGZ. and Marchenko, V. (2016b) Effects of vagotomy on hypoglossal and phrenic responses to hypercapnia in the decerebrate rat. Respiratory Physiology Neurobiology 232, 13-21.

Guyenet, PG., Stornetta, RL, Souza, GMPR., Abbott, SBG., Shi, Y. and Bayliss, DA. (2019) The retrotrapezoid nucleus: central chemoreceptor and regulator of breathing automaticity. Trends in Neurosciences 42, 807-824

Ghali, MGZ. (2019b) Rubral modulation of breathing. Experimental Physiology 104, 1595-1604.

Schmid, K., Böhmer, G. and Fallert, M. (1988) Influence of rubrospinal tract and the adjacent mesencephalic reticular formation on the activity of medullary respiratory neurons and the phrenic nerve discharge in the rabbit. Pfliigers Archiv 413, 23-31.

Marchenko, V. and Rogers, R. F. (2007a) Retention of lung distension information in pump cell spike trains. American Journal of Physiology - Regulatory Integrative Comparative Physiology 293, R343-R353.

Takakura, AC., Moreira, TS., West, GH., Gwilt, JM., Colombari, E., Stornetta, RL. and Guyenet, PG. GABAergic pump cells of solitary tract nucleus innervate retrotrapezoid nucleus chemoreceptors. Journal of Neurophysiology 98, 374-381.

Marchenko, V., Koizumi, H., Mosher, B., Koshiya, N., Tariq, M. F., Bezdudnaya, TG., Zhang, R., Molkov, YI., Rybak, I. A. and Smith, J. C. (2016) Perturbations of Respiratory Rhythm and Pattern by Disrupting Synaptic Inhibition within Pre-Bötzinger and Bötzinger Complexes. Eneuro 3. pii: ENEURO.0011-16.2016.

Kuwana, S., Tsunekawa, N., Yanagawa, N., Okada, Y., Kuribayashi, J. and Obata, K. (2006) Electrophysiological and morphological characteristics of GABAergic respiratory neurons in the mouse pre-Bötzinger complexes. European Journal of Neuroscience 23, 667-674.

Koizumi, H. and Smith, JC. (2008) Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre- Bötzinger complex in vitro. Journal of Neuroscience 28, 1773-1785.

Toporikova, N. and Butera, RJ. (2011) Two types of independent bursting mechanisms in inspiratory neurons: an integrative model. Journal of Computational Neuroscience 30, 515-528

Koizumi, H., John, TT., Chia, JX., Tariq, MF., Phillips, RS., Mosher, B., Chen, Y., Thompson, R., Zhang, R., Koshiya, N. and Smith, JC. (2018) Transient receptor potential channels TRPM4 and TRPC3 critically contribute to respiratory motor pattern formation but not rhythmogenesis in rodent brainstem circuits. Eneuro 5, 0332-17.2018.

Picardo, MCD., Sugimura, YK., Dorst, KE., Kallurkar, PS., Akins, VT., Ma, X., Teruyama, R., Guinamard, R., Kam, K., Saha, M. S., Del Negro, C. A. (2019) Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm. PLOS Biology 17, e2006094.

Phillips, RS., John, TT., Koizumi, H., Molkov, YI. and Smith, JC. (2019) Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model. eLife 8, e41555.

Vann, NC., Pham, FD., Hayes, JA., Kottick, A. and Del Negro, CA. (2016) Transient suppression of Dbx1 PreBötzinger interneurons disrupts breathing in adult mice. PLoS One 9, e0162418

Wang, X., Hayes, JA., Revill, AL., Song, H., Kottick, A., Vann, NC., LaMar, MD., Picardo, MC., Akins, VT., Funk, GD. and Del Negro, CA. (2014) Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice.Elife 3, e03427

Tonkovic-Capin, V., Stucke, AG., Stuth, EA., Tonkovic-Capin, M., Hopp, FA., McCrimmon, DR. and Zuperku, EJ. (2003) Differential processing of excitation by GABAergic gain modulation in canine caudal ventral respiratory group neurons. Journal of Neurophysiology 89, 862-870.

Marchenko, V., Koizumi, H., Mosher, B., Koshiya, N., Tariq, M. F., Bezdudnaya, TG., Zhang, R., Molkov, YI., Rybak, IA. and Smith, JC. (2016) Perturbations of Respiratory Rhythm and Pattern by Disrupting Synaptic Inhibition within Pre-Bötzinger and Bötzinger Complexes. Eneuro 3. pii: ENEURO.0011-16.2016.

Tan W, Pagliardini S, Yang P, Janczewski WA, Feldman JL. Projections of preBötzinger complex neurons in adult rats. J Comp Neurol. 2010;518(10):1862-1878. doi:10.1002/cne.22308

Onimaru, H. and Dutschmann, M. (2012) Calcium imaging of neuronal activity in the most rostral parafacial respiratory group of the newborn rat. Journal of Physiological Sciences 62, 71-77.

Ellenberger, HH. and Feldman, JL. (1990) Brainstem connections of the rostral ventral respiratory group of the rat. Brain Research 513, 35-42. Elsen, F. P. and Ramirez, J. M. (1998) Calcium currents of rhythmic neurons

Stornetta, RL., Rosin, DL., Wang, H., Sevigny, P., Weston, MC. and Guyenet, PG. (2003) A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex. Journal of Comparative Neurology 455, 499-512.

Dutschmann, M. and Herbert, H. (2006) The Kölliker-Fuse nucleus gates the post-inspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat. European Journal of Neuroscience 24, 1071-1084. Mörschel, M. and Dutschmann, M. (2009) Pontine respiratory activity involved in inspiratory/expiratory phase transition. Philosophical Transactions of the Royal Society B: Biological Sciences 364, 2517-2526

Li, G., Shao, C., Chen, Q., Wang, Q. and Yang, K. (2017) Accumulated GABA activates presynaptic GABAB receptors and inhibits both excitatory and inhibitory synaptic transmission in rat midbrain periaqueductal gray. Neuroreport 28, 313-318.

46. Ghali, MGZ. and Marchenko, V. (2016a) Patterns of phrenic nerve discharge following complete high cervical spinal cord injury in the decerebrate rat. Journal of Neurotrauma 33, 1115-1127

Ghali MGZ. Respiratory rhythm generation and pattern formation: oscillators and network mechanisms. J Integr Neurosci. 2019 Dec 30;18(4):481-517. doi: 10.31083/j.jin.2019.04.188. PMID: 31912709.

Smith, JC., Abdala, AP., Rybak, IA. and Paton, JF. (2009) Structural and functional architecture of respiratory networks in the mammalian brainstem. Philosophical Transactions of the Royal Society of London B: Biological Sciences 364, 2577-2587

Molkov, YI., Rubin, JE., Rybak, IA. and Smith, JC. (2017) Computational models of the neural control of breathing. Wiley Interdisciplinary Reviews. Systems Biology and Medicine 9.

Paton, JF., Abdala, AP., Koizumi, H., Smith, JC. and St-John WM. (2006) Respiratory rhythm generation during gasping depends on persistent sodium current. Nature Neuroscience 9, 311-313.

Smith, JC., Abdala, AP., Koizumi, H., Rybak, IA. and Paton, JF. (2007) Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms. Journal of neurophysiology 98, 3370-3387.

Koizumi, H. and Smith, J. C. (2008) Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre- Bötzinger complex in vitro. Journal of Neuroscience 28, 1773

Rybak, IA., Shevtsova, NA., St-John, WM., Paton, JF and, Pierrefiche, O. (2003) Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies. European Journal of Neuroscience 18, 239-257.

Rolls ET. The functions of the orbitofrontal cortex. Brain Cogn. 2004 Jun;55(1):11-29. doi: 10.1016/S0278-2626(03)00277-X.

Benarroch EE. The central autonomic network: functional organization, dysfunction, and perspective. Mayo Clin Proc. 1993 Oct;68(10):988-1001. doi: 10.1016/s0025-6196(12)62272-1

Saper CB. The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Annu Rev Neurosci. 2002;25:433-69.

Alexandrov VG, Ivanova TG, Alexandrova NP. Prefrontal control of respiration. J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 1):17-23

Yasui Y, Breder CD, Saper CB, Cechetto DF. Autonomic responses and efferent pathways from the insular cortex in the rat. J Comp Neurol. 1991 Jan 15;303(3):355-74.

Moga MM, Herbert H, Hurley KM, Yasui Y, Gray TS, Saper CB. Organization of cortical, basal forebrain, and hypothalamic afferents to the parabrachial nucleus in the rat. J Comp Neurol. 1990 May 22;295(4):624-61.