Furkasyon Defektlerinin Tedavisinde Güncel Yaklaşımlar

Nibali L. Diagnosis and treatment of furcation-involved teeth. 2018.

Loos B, Nylund K, Claffey N, et al. Clinical effects of root debridement in molar and non-molar teeth. A 2-year follow-up. J Clin Periodontol. 1989;16(8):498-504.

Nordland P, Garrett S, Kiger R, et al. The effect of plaque control and root debridement in molar teeth. Journal of clinical periodontology. 1987;14(4):231-6.

McGuire MK, Nunn ME. Prognosis versus actual outcome. III. The effectiveness of clinical parameters in accurately predicting tooth survival. Journal of periodontology. 1996;67(7):666-74.

Dannewitz B, Krieger JK, Hüsing J, et al. Loss of molars in periodontally treated patients: a retrospective analysis five years or more after active periodontal treatment. Journal of Clinical Periodontology. 2006;33(1):53-61.

Al-Shammari KF, Kazor CE, Wang HL. Molar root anatomy and management of furcation defects. J Clin Periodontol. 2001;28(8):730-40.

Lowman JV, Burke RS, Pelleu GB. Patent accessory canals: incidence in molar furcation region. Oral Surg Oral Med Oral Pathol. 1973;36(4):580-4.

Carnevale G, Pontoriero R, Hürzeler MB. Management of furcation involvement. Periodontol 2000. 1995;9:69-89.

Matthews DC, Tabesh M. Detection of localized tooth-related factors that predispose to periodontal infections. Periodontol 2000. 2004;34:136-50.

Leknes KN. The influence of anatomic and iatrogenic root surface characteristics on bacterial colonization and periodontal destruction: a review. J Periodontol. 1997;68(6):507-16.

Huynh-Ba G, Kuonen P, Hofer D, et al. The effect of periodontal therapy on the survival rate and incidence of complications of multirooted teeth with furcation involvement after an observation period of at least 5 years: a systematic review. J Clin Periodontol. 2009;36(2):164-76.

Karoussis IK, Salvi GE, Heitz-Mayfield LJ, et al. Long-term implant prognosis in patients with and without a history of chronic periodontitis: a 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res. 2003;14(3):329-39.

Parihar AS, Katoch V. Furcation involvement & its treatment: a review. Journal of Advanced Medical and Dental Sciences Research. 2015;3(1):81.

Carnevale G, Pontoriero R, Hürzeler MB. Management of furcation involvement. Periodontology 2000. 1995;9(1):69-89.

Blomlöf L, Jansson L, Appelgren R, et al. Prognosis and mortality of root-resected molars. Int J Periodontics Restorative Dent. 1997;17(2):190-201.

Carnevale G, Pontoriero R, di Febo G. Long-term effects of root-resective therapy in furcation-involved molars. A 10-year longitudinal study. J Clin Periodontol. 1998;25(3):209-14.

Basten CH, Ammons WF, Jr., Persson R. Long-term evaluation of root-resected molars: a retrospective study. Int J Periodontics Restorative Dent. 1996;16(3):206-19.

Lee KL, Corbet EF, Leung WK. Survival of molar teeth after resective periodontal therapy--a retrospective study. J Clin Periodontol. 2012;39(9):850-60.

Derks H, Westheide D, Pfefferle T, et al. Retention of molars after root-resective therapy: a retrospective evaluation of up to 30 years. Clin Oral Investig. 2018;22(3):1327-35.

Takei HH, Han TJ, Carranza FA, Jr., et al. Flap technique for periodontal bone implants. Papilla preservation technique. J Periodontol. 1985;56(4):204-10.

Aslan S, Buduneli N, Cortellini P. Entire papilla preservation technique in the regenerative treatment of deep intrabony defects: 1-Year results. J Clin Periodontol. 2017;44(9):926-32.

Laugisch O, Cosgarea R, Nikou G, et al. Histologic evidence of periodontal regeneration in furcation defects: a systematic review. Clin Oral Investig. 2019;23(7):2861-906.

Karring T, Nyman S, Gottlow J, et al. Development of the biological concept of guided tissue regeneration--animal and human studies. Periodontol 2000. 1993;1:26-35.

Pontoriero R, Nyman S, Ericsson I, et al. Guided tissue regeneration in surgically-produced furcation defects. An experimental study in the beagle dog. J Clin Periodontol. 1992;19(3):159-63.

Karring T, Nyman S, Lindhe J. Healing following implantation of periodontitis affected roots into bone tissue. J Clin Periodontol. 1980;7(2):96-105.

Murphy KG, Gunsolley JC. Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Ann Periodontol. 2003;8(1):266-302.

Jepsen S, Eberhard J, Herrera D, et al. A systematic review of guided tissue regeneration for periodontal furcation defects. What is the effect of guided tissue regeneration compared with surgical debridement in the treatment of furcation defects? Journal of clinical periodontology. 2002;29:103-16.

Chen T-H, Tu Y-K, Yen C-C, et al. A systematic review and meta-analysis of guided tissue regeneration/osseous grafting for the treatment of Class II furcation defects. Journal of Dental Sciences. 2013;8(3):209-24.

Herr Y, Matsuura M, Lin WL, et al. The origin of fibroblasts and their role in the early stages of horizontal furcation defect healing in the beagle dog. J Periodontol. 1995;66(8):716-30.

Dogan A, Taner L, Oygür T, et al. Effects of fibrin adhesive material (Tissucol) application on furcation defects in dogs. J Nihon Univ Sch Dent. 1992;34(1):34-41.

Amin HD, Olsen I, Knowles JC, et al. Effects of enamel matrix proteins on multi-lineage differentiation of periodontal ligament cells in vitro. Acta Biomater. 2013;9(1):4796-805.

Amin HD, Olsen I, Knowles J, et al. Interaction of enamel matrix proteins with human periodontal ligament cells. Clin Oral Investig. 2016;20(2):339-47.

Casarin RC, Ribeiro Edel P, Nociti FH, Jr., et al. Enamel matrix derivative proteins for the treatment of proximal class II furcation involvements: a prospective 24-month randomized clinical trial. J Clin Periodontol. 2010;37(12):1100-9.

Jepsen S, Heinz B, Jepsen K, et al. A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars. Part I: Study design and results for primary outcomes. J Periodontol. 2004;75(8):1150-60.

Raja S, Byakod G, Pudakalkatti P. Growth factors in periodontal regeneration. Int J Dent Hyg. 2009;7(2):82-9.

Murakami S, Takayama S, Kitamura M, et al. Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs. J Periodontal Res. 2003;38(1):97-103.

Takayama S, Murakami S, Shimabukuro Y, et al. Periodontal regeneration by FGF-2 (bFGF) in primate models. J Dent Res. 2001;80(12):2075-9.

Teare J, Petit JC, Ripamonti U. Synergistic induction of periodontal tissue regeneration by binary application of human osteogenic protein‐1 and human transforming growth factor‐β3 in Class II furcation defects of Papio ursinus. Journal of periodontal research. 2012;47(3):336-44.

Soares FP, Hayashi F, Yorioka CW, et al. Repair of Class II furcation defects after a reparative tissue graft obtained from extraction sockets treated with growth factors: a histologic and histometric study in dogs. Journal of periodontology. 2005;76(10):1681-9.

Ripamonti U, Heliotis M, van den Heever B, et al. Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus). J Periodontal Res. 1994;29(6):439-45.

Seo BM, Miura M, Gronthos S, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364(9429):149-55.

Huang GT, Sonoyama W, Chen J, et al. In vitro characterization of human dental pulp cells: various isolation methods and culturing environments. Cell Tissue Res. 2006;324(2):225-36.

MATUR İ, SOLMAZ S. Kök Hücre Üretiminde Güncel Yaklaşımlar. Arşiv Kaynak Tarama Dergisi. 2011;20(3):168-86.

Mattar P, Bieback K. Comparing the Immunomodulatory Properties of Bone Marrow, Adipose Tissue, and Birth-Associated Tissue Mesenchymal Stromal Cells. Front Immunol. 2015;6:560.

Suaid FF, Ribeiro FV, Rodrigues TL, et al. Autologous periodontal ligament cells in the treatment of class II furcation defects: a study in dogs. J Clin Periodontol. 2011;38(5):491-8.

Chantarawaratit P, Sangvanich P, Banlunara W, et al. Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model. J Periodontal Res. 2014;49(2):164-78.

Yang JR, Hsu CW, Liao SC, et al. Transplantation of embryonic stem cells improves the regeneration of periodontal furcation defects in a porcine model. J Clin Periodontol. 2013;40(4):364-71.

Niederman R, Savitt ED, Heeley JD, et al. Regeneration of furca bone using Gore-Tex periodontal material. Int J Periodontics Restorative Dent. 1989;9(6):468-80.

Pontoriero R, Lindhe J, Nyman S, et al. Guided tissue regeneration in the treatment of furcation defects in mandibular molars. A clinical study of degree III involvements. J Clin Periodontol. 1989;16(3):170-4.

White C, Jr., Hancock EB, Garetto LP, et al. A histomorphometric study on the healing of class III furcations utilizing bone labelling in beagle dogs. J Periodontol. 1994;65(1):84-92.

Lindhe J, Pontoriero R, Berglundh T, et al. The effect of flap management and bioresorbable occlusive devices in GTR treatment of degree III furcation defects. An experimental study in dogs. J Clin Periodontol. 1995;22(4):276-83.

Araújo MG, Berglundh T, Lindhe J. GTR treatment of degree III furcation defects with 2 different resorbable barriers. An experimental study in dogs. J Clin Periodontol. 1998;25(3):253-9.

Roriz VM, Souza SL, Taba M, Jr., et al. Treatment of Class III furcation defects with expanded polytetrafluoroethylene membrane associated or not with anorganic bone matrix/synthetic cell-binding peptide: a histologic and histomorphometric study in dogs. J Periodontol. 2006;77(3):490-7.

Saito E, Saito A, Kuboki Y, et al. Periodontal repair following implantation of beta-tricalcium phosphate with different pore structures in Class III furcation defects in dogs. Dent Mater J. 2012;31(4):681-8.

Araújo MG, Lindhe J. GTR treatment of degree III furcation defects following application of enamel matrix proteins. An experimental study in dogs. J Clin Periodontol. 1998;25(6):524-30.

Shirakata Y, Miron RJ, Nakamura T, et al. Effects of EMD liquid (Osteogain) on periodontal healing in class III furcation defects in monkeys. J Clin Periodontol. 2017;44(3):298-307.

Mardas N, Kraehenmann M, Dard M. Regenerative wound healing in acute degree III mandibular defects in dogs. Quintessence International. 2012;43(5).

Donos N, Sculean A, Glavind L, et al. Wound healing of degree III furcation involvements following guided tissue regeneration and/or Emdogain. A histologic study. J Clin Periodontol. 2003;30(12):1061-8.

Gkranias ND, Graziani F, Sculean A, et al. Wound healing following regenerative procedures in furcation degree III defects: histomorphometric outcomes. Clin Oral Investig. 2012;16(1):239-49.

Saito A, Saito E, Kuboki Y, et al. Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs. Dent Mater J. 2013;32(2):256-62.

Rossa C, Jr., Marcantonio E, Jr., Cirelli JA, et al. Regeneration of Class III furcation defects with basic fibroblast growth factor (b-FGF) associated with GTR. A descriptive and histometric study in dogs. J Periodontol. 2000;71(5):775-84.

Mellonig JT, Valderrama Mdel P, Cochran DL. Histological and clinical evaluation of recombinant human platelet-derived growth factor combined with beta tricalcium phosphate for the treatment of human Class III furcation defects. Int J Periodontics Restorative Dent. 2009;29(2):169-77.

Yan XZ, Ge SH, Sun QF, et al. A pilot study evaluating the effect of recombinant human bone morphogenetic protein-2 and recombinant human beta-nerve growth factor on the healing of Class III furcation defects in dogs. J Periodontol. 2010;81(9):1289-98.

Suaid FF, Ribeiro FV, Gomes TR, et al. Autologous periodontal ligament cells in the treatment of Class III furcation defects: a study in dogs. J Clin Periodontol. 2012;39(4):377-84.

Murano Y, Ota M, Katayama A, et al. Periodontal regeneration following transplantation of proliferating tissue derived from periodontal ligament into class III furcation defects in dogs. Biomed Res. 2006;27(3):139-47.

Jiang J, Wu X, Lin M, et al. Application of autologous periosteal cells for the regeneration of class III furcation defects in Beagle dogs. Cytotechnology. 2010;62(3):235-43.

Nagahara T, Yoshimatsu S, Shiba H, et al. Introduction of a mixture of β-tricalcium phosphate into a complex of bone marrow mesenchymal stem cells and type I collagen can augment the volume of alveolar bone without impairing cementum regeneration. J Periodontol. 2015;86(3):456-64.

Mills MP, Rosen PS, Chambrone L, et al. American Academy of Periodontology best evidence consensus statement on the efficacy of laser therapy used alone or as an adjunct to non-surgical and surgical treatment of periodontitis and peri-implant diseases. J Periodontol. 2018;89(7):737-42.

de Andrade AK, Feist IS, Pannuti CM, et al. Nd:YAG laser clinical assisted in class II furcation treatment. Lasers Med Sci. 2008;23(4):341-7.

Crespi R, Covani U, Margarone JE, et al. Periodontal tissue regeneration in beagle dogs after laser therapy. Lasers Surg Med. 1997;21(4):395-402.

Mizutani K, Aoki A, Takasaki AA, et al. Periodontal tissue healing following flap surgery using an Er:YAG laser in dogs. Lasers Surg Med. 2006;38(4):314-24.

Ge L, Zhang Y, Shu R. Er,Cr:YSGG Laser Application for the Treatment of Periodontal Furcation Involvements. Photomed Laser Surg. 2017;35(2):92-7.

Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci. 2004;3(5):436-50.

Luchesi VH, Pimentel SP, Kolbe MF, et al. Photodynamic therapy in the treatment of class II furcation: a randomized controlled clinical trial. J Clin Periodontol. 2013;40(8):781-8.

de Almeida JM, Theodoro LH, Bosco AF, et al. In vivo effect of photodynamic therapy on periodontal bone loss in dental furcations. J Periodontol. 2008;79(6):1081-8.

Matesanz-Pérez P, García-Gargallo M, Figuero E, et al. A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis. J Clin Periodontol. 2013;40(3):227-41.

Sgolastra F, Gatto R, Petrucci A, et al. Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis. J Periodontol. 2012;83(10):1257-69.

Keestra JA, Grosjean I, Coucke W, et al. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta-analysis. J Periodontal Res. 2015;50(3):294-314.

Eickholz P, Nickles K, Koch R, et al. Is furcation involvement affected by adjunctive systemic amoxicillin plus metronidazole? A clinical trials exploratory subanalysis. J Clin Periodontol. 2016;43(10):839-48.

Ting M, Whitaker EJ, Albandar JM. Systematic review of the in vitro effects of statins on oral and perioral microorganisms. Eur J Oral Sci. 2016;124(1):4-10.

Meza-Mauricio J, Soto-Peñaloza D, Peñarrocha-Oltra D, et al. Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis. Clin Oral Investig. 2018;22(7):2413-30.

Bertl K, Parllaku A, Pandis N, et al. The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy-A systematic review and meta-analysis. J Dent. 2017;67:18-28.

Sinjab K, Zimmo N, Lin GH, et al. The Effect of Locally Delivered Statins on Treating Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. J Periodontol. 2017;88(4):357-67.

Kırzıoğlu FY, Özmen Ö, Doğan B, et al. Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis. J Periodontal Res. 2018;53(2):258-66.

Messora MR, Apolinário Vieira GH, Vanderlei J, et al. Rosuvastatin promotes benefits on induced periodontitis in hypertensive rats. J Periodontal Res. 2017;52(4):734-44.

Pradeep AR, Karvekar S, Nagpal K, et al. Rosuvastatin 1.2 mg In Situ Gel Combined With 1:1 Mixture of Autologous Platelet-Rich Fibrin and Porous Hydroxyapatite Bone Graft in Surgical Treatment of Mandibular Class II Furcation Defects: A Randomized Clinical Control Trial. J Periodontol. 2016;87(1):5-13.

Garg S, Pradeep AR. 1.2% Rosuvastatin and 1.2% Atorvastatin Gel Local Drug Delivery and Redelivery in the Treatment of Class II Furcation Defects: A Randomized Controlled Clinical Trial. J Periodontol. 2017;88(3):259-65.

Avila-Ortiz G, De Buitrago JG, Reddy MS. Periodontal regeneration - furcation defects: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015;86(2 Suppl):S108-30.

Aichelmann-Reidy ME, Avila-Ortiz G, Klokkevold PR, et al. Periodontal Regeneration - Furcation Defects: Practical Applications From the AAP Regeneration Workshop. Clin Adv Periodontics. 2015;5(1):30-9.