Effects of Psychiatric Medications on Lipid and Glucose Metabolism

van Nimwegen LJM, Storosum JG, Blumer RME et al. Hepatic Insulin Resistance in Antipsychotic Naive Schizophrenic Patients: Stable Isotope Studies of Glucose Metabolism. The Journal of Clinical Endocrinology and Metabolism. 2008 Feb 1;93(2):572–7. doi:10.1210/jc.2007-1167

Henderson DC, Cagliero E, Copeland PM et al. Glucose Metabolism in Patients With Schizophrenia Treated With Atypical Antipsychotic Agents: A Frequently Sampled Intravenous Glucose Tolerance Test and Minimal Model Analysis. Archives of General Psychiatry. 2005 Jan 1;62(1):19–28. doi:10.1001/archpsyc.62.1.19

Starrenburg FCJ, Bogers JPAM. How can antipsychotics cause diabetes mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins. Vol. 24, European Psychiatry. 2009. p. 164–70. doi:10.1016/j.eurpsy.2009.01.001

Chintoh AF, Mann SW, Lam L et al. Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model. Schizophrenia Research. 2009;108(1–3):127–33. doi:10.1016/j.schres.2008.12.012

Peterson HR, Rothschild M, Weinberg CR et al. Body fat and the activity of the autonomic nervous system. New England Journal of Medicine. 1988;318(17):1077–83. doi:10.1056/NEJM198804283181701

Bennet H, Balhuizen A, Medina A et al. Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes. Peptides. 2015;71:113–20. doi:10.1016/j.peptides.2015.07.008

Wirshing DA, Spellberg BJ, Erhart SM et al. Novel antipsychotics and new onset diabetes. Biological Psychiatry. 1998;44(8):778–83. doi:10.1016/S0006-3223(98)00100-0

Gautam D, Han SJ, Hamdan FF et al. A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metabolism. 2006;3(6):449–61. doi:10.1016/j.cmet.2006.04.009

Nasrallah HA. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Molecular Psychiatry. 2008;13(1):27–35. doi:10.1038/sj.mp.4002066

Scheen AJ, de Hert MA. Abnormal glucose metabolism in patients treated with antipsychotics. Diabetes and Metabolism. 2007;33(3):169–75. doi:10.1016/j.diabet.2007.01.003

Carnovale C, Lucenteforte E, Battini V et al. Association between the glyco-metabolic adverse effects of antipsychotic drugs and their chemical and pharmacological profile: a network meta-analysis and regression. Psychological Medicine. 2022;52(15):3508–20. doi:10.1017/S0033291721000180

Masaki T, Chiba S, Yasuda T et al. Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Diabetes. 2004;53(9):2250–60. doi:10.2337/diabetes.53.9.2250

Leslie DL, Rosenheck RA. Incidence of newly diagnosed diabetes attributable to atypical antipsychotic medications. American Journal of Psychiatry. 2004;161(9):1709–11. doi:10.1176/appi.ajp.161.9.1709

Mahmoud RA, Wang R hua, Nasrallah HA. Differential Effects of Bisperidone, Olanzapine, Clozapine, and Conventional Antipsychotics on Type 2 Diabetes: Findings From a Large Health Plan Database. Journal of Clinical Psychiatry. 2002;63(10):920–30. doi:10.4088/jcp.v63n1010

Simpson N, Maffei A, Freeby M et al. Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro. Molecular Endocrinology. 2012 Aug 21;26:1757–72. doi:10.1210/me.2012-1101

Arranz B, Rosel P, Ramirez N et al. Insulin Resistance and Increased Leptin Concentrations in Noncompliant Schizophrenia Patients but Not in Antipsychotic-Naive First-Episode Schizophrenia Patients. The Journal of Clinical Psychiatry. 2004 Nov 1;65:1335–42. doi:10.4088/JCP.v65n1007

Hanssens L, van Winkel R, Wampers M et al. A cross-sectional evaluation of adiponectin plasma levels in patients with schizophrenia and schizoaffective disorder. Schizophrenia Research. 2008;106(2–3):308–14. doi:10.1016/j.schres.2008.09.008

Dwyer DS, Pinkofsky HB, Liu Y et al. Antipsychotic drugs affect glucose uptake and the expression of glucose transporters in PC12 cells. Progress in Neuropsychopharmacology and Biological Psychiatry. 1999;23(1):69–80. doi:10.1016/s0278-5846(98)00092-x.

Dwyer DS, Lu XH, Bradley RJ. Cytotoxicity of conventional and atypical antipsychotic drugs in relation to glucose metabolism. Brain Research. 2003;971(1):31–9. doi: 10.1016/s0006-8993(03)02351-5.

Castellani LN, Pereira S, Kowalchuk C et al. Antipsychotics impair regulation of glucose metabolism by central glucose. Molecular Psychiatry. 2022;27(11):4741–53. doi: 10.1038/s41380-022-01798-y.

Stapel B, Kotsiari A, Scherr M et al. Olanzapine and aripiprazole differentially affect glucose uptake and energy metabolism in human mononuclear blood cells. Journal of Psychiatric Research. 2016 Dec 22;88:18–27. doi:10.1016/j.jpsychires.2016.12.012.

Keskiner A, El Toumi A, Bousquet T. Psychotropic Drugs, Diabetes and Gironic Mental Patients. Psychosomatics. 1973;14(3):176–81. doi:10.1016/s0033-3182(73)71353-0.

Lindenmayer JP, Czobor P, Volavka J et al. Changes in Glucose and Cholesterol Levels in Patients With Schizophrenia Treated With Typical or Atypical Antipsychotics. The American Journal of Psychiatry. 2003 Feb 1;160:290–6. doi:10.1176/appi.ajp.160.2.290.

Wang PS, Glynn RJ, Ganz DA et al. Clozapine use and risk of diabetes mellitus. Journal of Clinical Psychopharmacology. 2002;22(3):236–43. doi:10.1097/00004714-200206000-00002.

Sernyak MJ, Leslie DL, Alarcon RD et al. Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia. American Journal of Psychiatry. 2002;159(4):561–6. doi:10.1176/appi.ajp.159.4.561.

Sumiyoshi T, Roy A, Anil AE et al. A Comparison of Incidence of Diabetes Mellitus Between Atypical Antipsychotic Drugs: A Survey for Clozapine, Risperidone, Olanzapine, and Quetiapine. Journal of Clinical Psychopharmacology. 2004;24(3). doi: 10.1097/01.jcp.0000126668.67820.00.

Zhang R, Hao W, Pan M et al. The prevalence and clinical‐demographic correlates of diabetes mellitus in chronic schizophrenic patients receiving clozapine. Human Psychopharmacology: Clinical and Experimental. 2011 Aug 1;26:392–6. doi: 10.1002/hup.1220.

Hasnain M, Vieweg WVR, Hollett B. Weight Gain and Glucose Dysregulation with Second-Generation Antipsychotics and Antidepressants: A Review for Primary Care Physicians. Postgraduate Medicine. 2012 Jul 1;124(4):154–67. doi:10.3810/pgm.2012.07.2577

Pillinger T, McCutcheon RA, Vano L et al. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry. 2020;7(1):64–77. doi:10.1016/S2215-0366(19)30416-X.

Jafari S, Fernandez‐Enright F, Huang X. Structural contributions of antipsychotic drugs to their therapeutic profiles and metabolic side effects. Journal of Neurochemistry. 2012;120(3):371–84. doi:10.1111/j.1471-4159.2011.07590.x.

Rummel-Kluge C, Komossa K, Schwarz S et al. Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophrenia Research. 2010;123(2–3):225–33. doi:10.1016/j.schres.2010.07.012.

Church CO, Stevens DL, Fugate SE. Diabetic ketoacidosis associated with aripiprazole. Diabetic medicine. 2005;22(10):1440–3. doi:10.1111/j.1464-5491.2005.01628.x.

Makhzoumi ZH, McLean LP, Lee JH et al. Diabetic ketoacidosis associated with aripiprazole. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2008;28(9):1198–202. doi:10.1592/phco.28.9.1198.

Rubin DM, Kreider AR, Matone M et al. Risk for incident diabetes mellitus following initiation of second-generation antipsychotics among Medicaid-enrolled youths. JAMA Pediatrics. 2015;169(4):e150285–e150285. doi:10.1001/jamapediatrics.2015.0285.

Garnock-Jones KP. Brexpiprazole: A Review in Schizophrenia. CNS Drugs. 2016;30(4):335–42. doi:10.1007/s40263-016-0325-8

Lao K, He Y, Wong I et al. Tolerability and Safety Profile of Cariprazine in Treating Psychotic Disorders, Bipolar Disorder and Major Depressive Disorder: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. CNS Drugs. 2016 Aug 22;30. doi:10.1007/s40263-016-0382-z.

Stahl S, Cucchiaro J, Simonelli D et al. Effectiveness of Lurasidone for Patients With Schizophrenia Following 6 Weeks of Acute Treatment With Lurasidone, Olanzapine, or Placebo: A 6-Month, Open-Label, Extension Study. Journal of Clinical Psychiatry. 2013 Mar 13;74. doi:10.4088/JCP.12m08084.

McIntyre RS, Cohen M, Zhao J et al. Asenapine for long-term treatment of bipolar disorder: A double-blind 40-week extension study. Journal of Affective Disorders. 2010;126(3):358–65. doi:10.1016/j.jad.2010.04.005.

Misiak B, Stańczykiewicz B, Łaczmański Ł et al. Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis: A systematic review and meta-analysis. Schizophrenia Research. 2017;190:18–27. doi:10.1016/j.schres.2017.03.031.

Ulivieri M, Wierońska JM, Lionetto L et al. The trace kynurenine, cinnabarinic acid, displays potent antipsychotic-like activity in mice and its levels are reduced in the prefrontal cortex of individuals affected by schizophrenia. Schizophrenia Bulletin. 2020;46(6):1471–81. doi:10.1093/schbul/sbaa074.

Zhang Y, Wang Q, Reynolds G et al. Metabolic Effects of 7 Antipsychotics on Patients With Schizophrenia: A Short-Term, Randomized, Open-Label, Multicenter, Pharmacologic Trial. Journal of Clinical Psychiatry. 2020 Mar 24;81. doi:10.4088/JCP.19m12785.

Pereira S, Au E, Agarwal SM et al. Antipsychotic-induced alterations in lipid turnover. Endocrinology. 2023;bqad025. doi:10.1210/endocr/bqad025.

Li R, Zhang Y, Zhu W et al. Effects of olanzapine treatment on lipid profiles in patients with schizophrenia: A systematic review and meta-analysis. Scientific Reports. 2020;10(1):17028. doi:10.1038/s41598-020-73983-4.

Boyda HN, Pham M, Huang J et al. Antipsychotic drug-induced increases in peripheral catecholamines are associated with glucose intolerance. Frontiers in Pharmacology. 2022;13:208. doi:10.3389/fphar.2022.765905.

Korade Z, Liu W, Warren EB et al. Effect of psychotropic drug treatment on sterol metabolism. Schizophrenia Research. 2017;187:74–81. doi:10.1016/j.schres.2017.02.001.

Liu X, Wu Z, Lian J et al. Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats. Scientific Reports. 2017;7(1):1–13. doi:10.1038/s41598-017-02884-w.

Balog M, Anderson A, Genaro-Mattos TC et al. Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain. Journal of Lipid Research. 2022;63(8). doi:10.1016/j.jlr.2022.100249.

Sarsenbayeva A, Marques-Santos CM, Thombare K et al. Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism. Psychoneuroendocrinology. 2019;110:104445. doi:10.1016/j.psyneuen.2019.104445.

Fu Y, Yang K, Huang Y et al. Deciphering Risperidone-Induced Lipogenesis by Network Pharmacology and Molecular Validation. Frontiers in Psychiatry. 2022;13. doi:10.3389/fpsyt.2022.870742.

Vantaggiato C, Panzeri E, Citterio A et al. Antipsychotics promote metabolic disorders disrupting cellular lipid metabolism and trafficking. Trends in Endocrinology & Metabolism. 2019;30(3):189–210. doi:10.1016/j.tem.2019.01.003.

Stapel B, Kotsiari A, Scherr M et al. Olanzapine and aripiprazole differentially affect glucose uptake and energy metabolism in human mononuclear blood cells. Journal of Psychiatric Research. 2016 Dec 22;88:18–27. doi:10.1016/j.jpsychires.2016.12.012.

Zhang Y, Wang Q, Reynolds GP et al. Metabolic effects of 7 antipsychotics on patients with schizophrenia: a short-term, randomized, open-label, multicenter, pharmacologic trial. The Journal of Clinical Psychiatry. 2020;81(3):16879. doi:10.4088/JCP.19m12785.

Henderson D, Cagliero E, Gray C et al. Clozapine, Diabetes Mellitus, Weight Gain, and Lipid Abnormalities: A Five-Year Naturalistic Study. The American Journal of Psychiatry. 2000 Jul 1;157:975–81. doi:10.1176/appi.ajp.157.6.975.

Fan X, Borba C, Copeland P et al. Metabolic effects of adjunctive aripiprazole in clozapine-treated patients with schizophrenia. Acta Psychiatrica Scandinavica. 2012 Sep 4;127. doi:10.1111/acps.12009.

Dhar AK, Barton DA. Depression and the Link with Cardiovascular Disease. Frontiers in Psychiatry. 2016;7. doi:10.3389/fpsyt.2016.00033.

McIntyre RS, Mancini DA, Pearce MM et al. Mood and Psychotic Disorders and Type 2 Diabetes: A Metabolic Triad. Canadian Journal of Diabetes, 2005 29(2), 122–132.

Stuchtey FC, Block A, Osei F et al. Lipid Biomarkers in Depression: Does Antidepressant Therapy Have an Impact? Healthcare (Basel). 2022 Feb 9;10(2):333. doi:10.3390/healthcare10020333.

Dinan TG. Inflammatory markers in depression. Current Opinion in Psychiatry. 2009;22(1):32–6. doi:10.1097/YCO.0b013e328315a561.

Chen X, Xun K, Chen L et al. TNF‐α, a potent lipid metabolism regulator. Cell Biochemistry and Function. 2009;27(7):407–16. doi:10.1002/cbf.1596.

Senn JJ, Klover PJ, Nowak IA et al. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. Journal of Biological Chemistry. 2003;278(16):13740–6. doi:10.1074/jbc.M210689200.

Narita K, Murata T, Takahashi T et al. Plasma levels of adiponectin and tumor necrosis factor-alpha in patients with remitted major depression receiving long-term maintenance antidepressant therapy. Progress in Neuropsychopharmacology and Biological Psychiatry. 2006;30(6):1159–62. doi:10.1016/j.pnpbp.2006.03.030.

McIntyre RS, Soczynska JK, Konarski JZ et al. The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms. Expert Opinion in Drug Safety. 2006;5(1):157–68. doi:10.1517/14740338.5.1.157.

Kivimäki M, Hamer M, Batty GD et al. Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based study. Diabetes Care. 2010;33(12):2611–6. doi:10.2337/dc10-1187.

Andersohn F, Schade R, Suissa S et al. Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. American Journal of Psychiatry. 2009;166(5):591–8. doi:10.1176/appi.ajp.2008.08071065.

Baumeister H, Hutter N, Bengel J. Psychological and pharmacological interventions for depression in patients with diabetes mellitus and depression. Cochrane Database of Systematic Reviews. 2012;(12). doi:10.1002/14651858.CD008381.pub2.

Jindal RD. Long-term antidepressant use and risk for diabetes: cause for concern and optimism. American Journal of Psychiatry. 2009;166(9):1065–6. doi:10.1176/appi.ajp.2009.09050629.

Dandjinou M, Sheehy O, Bérard A. Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case–control study. BMJ Open. 2019;9(9):e025908. doi:10.1136/bmjopen-2018-025908.

Kuo HY, Chen HM, Lee CC et al. Antidepressants and risk of type 2 diabetes mellitus: a population-based nested case-control study. Journal of Clinical Psychopharmacology. 2020;40(4):359–65. doi:10.1097/JCP.0000000000001228.

Fagerholm V, Haaparanta M, Scheinin M. α2‐Adrenoceptor regulation of blood glucose homeostasis. Basic Clinical Pharmacology Toxicology. 2011;108(6):365–70. doi:10.1111/j.1742-7843.2011.00699.x.

Crucitti A, Zhang Q, Nilsson M et al. Duloxetine treatment and glycemic controls in patients with diagnoses other than diabetic peripheral neuropathic pain: a meta-analysis. Current Medical Research and Opinion. 2010 Nov 1;26(11):2579–88. doi:10.1185/03007991003769241

Nonogaki K, Nozue K, Kuboki T et al. Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2007;292(5):R1775–81. doi:10.1152/ajpregu.00527.2006.

Szegedi A, Schwertfeger N. Mirtazapine: a review of its clinical efficacy and tolerability. Expert Opinion on Pharmacotherapy. 2005;6(4):631–41. doi:10.1517/14656566.6.4.631.

Song HR, Kwon YJ, Woo YS et al. Effects of Mirtazapine on Patients Undergoing Naturalistic Diabetes Treatment: A Follow-Up Study Extended From 6 to 12 Months. Journal of Clinical Psychopharmacology. 2015;35(6). doi:10.1097/JCP.0000000000000399.

Can ÖD, Üçel Uİ, Demir Özkay Ü et al. The effect of agomelatine treatment on diabetes-induced cognitive impairments in rats: concomitant alterations in the hippocampal neuron numbers. International Journal of Molecular Sciences. 2018;19(8):2461. doi:10.3390/ijms19082461

Ježová D, Dunčko R. Enhancement of stress-induced pituitary hormone release and cardiovascular activation by antidepressant treatment in healthy men. Journal of Psychopharmacology. 2002;16(3):235–40. doi:10.1177/026988110201600308.

Goodnick PJ, Breakstone K, Kumar A et al. Nefazodone in diabetic neuropathy: response and biology. Psychosomatic Medicine. 2000;62(4):599–600. doi:10.1097/00006842-200007000-00020.

Bilici M, Efe H, Köroğlu MA et al. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. Journal of Affective Disorders. 2001;64(1):43–51. doi:10.1016/s0165-0327(00)00199-3.

Kopf D, Westphal S, Luley CW et al. Lipid Metabolism and Insulin Resistance in Depressed Patients: Significance of Weight, Hypercortisolism, and Antidepressant Treatment. Journal of Clinical Psychopharmacology. 2004;24(5). doi:10.1097/01.jcp.0000138762.23482.63.

Lemberger T, Saladin R, Vázquez M et al. Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. Journal of Biological Chemistry. 1996 Jan 19;271(3):1764-9. doi:10.1074/jbc.271.3.1764.

Bailey DL, Le Mellédo JM. Effects of Selective Serotonin Reuptake Inhibitors on Cholesterol Levels in Patients with Panic Disorder. Journal of Clinical Psychopharmacology. 2003;23(3). doi:10.1097/00004714-200306000-00016.

Fisar Z, Anders M, Tvrzicka E et al. Effect of long-term administration of antidepressants on the lipid composition of brain plasma membranes. General Physiology and Biophysics. 2005 Jun 1;24:221–36. PMID: 16118474.

Pan S juan, Tan Y, Yao S wu et al. Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression. Acta Pharmacologica Sinica. 2018 May 1;39. doi:10.1038/aps.2017.207.

Adzic M, Brkic Z, Bulajic S et al. Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders. Drug Development Research [Internet]. 2016 Nov 1;77(7):400–6. doi:10.1002/ddr.21332

Amiya E. Interaction of hyperlipidemia and reactive oxygen species: insights from the lipid-raft platform. World Journal of Cardiology. 2016;8(12):689. doi:10.4330/wjc.v8.i12.689.

Bilici M, Efe H, Köroğlu MA et al. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. Journal of Affective Disorder. 2001;64(1):43–51. doi:10.1016/s0165-0327(00)00199-3.

Beyazyüz M, Albayrak Y, Eğilmez O et al. Relationship between SSRIs and Metabolic Syndrome Abnormalities in Patients with Generalized Anxiety Disorder: A Prospective Study. Psychiatry Investigation. 2013 Jun 1;10:148–54. doi:10.4306/pi.2013.10.2.148.

Raeder M, Bjelland I, Vollset S et al. Obesity, Dyslipidemia, and Diabetes With Selective Serotonin Reuptake Inhibitors. Journal of Clinical Psychiatry. 2007 Jan 1;67:1974–82. doi:10.4088/jcp.v67n1219.

Visser M, Seidell JC, Koppeschaar HPF et al. No Specific Effect of Fluoxetine Treatment on Fasting Glucose, Insulin, Lipid Levels, and Blood Pressure in Healthy Men with Abdominal Obesity. Obesity Research. 1994 Mar 1;2(2):152–9. doi: 10.1002/j.1550-8528.1994.tb00641.x

Wernicke JF, Raskin J, Rosen A et al. Duloxetine in the long-term management of diabetic peripheral neuropathic pain: An open-label, 52-week extension of a randomized controlled clinical trial. Current Therapeutic Research. 2006;67(5):283–304. doi:10.1016/j.curtheres.2006.10.001.

Liebowitz M, Mangano R, Bradwejn J et al. A Randomized Controlled Trial of Venlafaxine Extended Release in Generalized Social Anxiety Disorder. The Journal of Clinical Psychiatry. 2005 Mar 1;66:238–47. doi:10.4088/jcp.v66n0213.

Laimer M, Kramer-Reinstadler K, Rauchenzauner M et al. Effect of mirtazapine treatment on body composition and metabolism. Journal of Clinical Psychiatry. 2006;67(3):421–4. doi:10.4088/jcp.v67n0313.

Hennings JM, Heel S, Lechner K et al. Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men. JCI Insight. 2019 Jan 10;4(1):e123786. doi:10.1172/jci.insight.123786.

Albouz S, Vanier MT, Hauw JJ et al. Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells. Neuroscience Letters. 1983;36(3):311–5. doi:10.1016/0304-3940(83)90018-6.

Olusi SO, Fido AA. Serum lipid concentrations in patients with major depressive disorder. Biological Psychiatry. 1996;40(11):1128–31. doi:10.1016/S0006-3223(95)00599-4.

Pollock BG, Perel JM, Paradis CF et al. Metabolic and physiologic consequences of nortriptyline treatment in the elderly. Psychopharmacology Bulletin. 1994;30(2):145-50. PMID: 7831447.

Yeragani VK, Balon R, Pohl R et al. Imipramine treatment and increased serum cholesterol levels. Canadian Journal of Psychiatry. 1989 Nov;34(8):845. doi:10.1177/070674378903400829.

Jain AK, Kaplan RA, Gadde KM et al. Bupropion SR vs. placebo for weight loss in obese patients with depressive symptoms. Obesity Research. 2002;10(10):1049–56. doi:10.1038/oby.2002.142.

Goldstein BI, Liu SM, Zivkovic N et al. The burden of obesity among adults with bipolar disorder in the United States. Bipolar Disorders. 2011;13(4):387-395. doi:10.1111/j.1399-5618.2011.00932.x

Steardo Jr L, Fabrazzo M, Sampogna G et al. Impaired glucose metabolism in bipolar patients and response to mood stabilizer treatments. Journal of Affective Disorders. 2019;245:174–9. doi:10.1016/j.jad.2018.10.360.

Hermida MA, Kumar JD, Leslie NR. GSK3 and its interactions with the PI3K/AKT/mTOR signalling network. Advances in Biological Regulation. 2017;65:5–15. doi:10.1016/j.jbior.2017.06.003.

de Groot T, Damen L, Kosse L et al. Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice. PLoS One. 2017;12(12):e0189485. doi:10.1371/journal.pone.0189485.

Gherardelli C, Cisternas P, Inestrosa NC. Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer’s Disease. International Journal of Molecular Sciences. 2022;23(15):8733. doi:10.3390/ijms23158733.

Lee J, Kim MS. The role of GSK3 in glucose homeostasis and the development of insulin resistance. Diabetes Research and Clinical Practice. 2007;77(3):S49–57. doi:10.1016/j.diabres.2007.01.033.

Calkin C, McClelland C, Cairns K et al. Insulin resistance and blood-brain barrier dysfunction underlie neuroprogression in bipolar disorder. Frontiers in Psychiatry. 2021;12:636174. doi:10.3389/fpsyt.2021.636174.

Calkin C V, Ruzickova M, Uher R et al. Insulin resistance and outcome in bipolar disorder. The British Journal of Psychiatry. 2015;206(1):52–7. doi:10.1192/bjp.bp.114.152850.

Ostrovskaya RU, Ivanov S V, Durnev AD. Neuroprotective lithium salts protect pancreatic β-сells from damage. Bulletin Experimental Biology and Medicine. 2018;165(6):758–62. doi:10.1007/s10517-018-4259-7.

Belcastro V, D’Egidio C, Striano P et al. Metabolic and endocrine effects of valproic acid chronic treatment. Epilepsy Research. 2013;107(1):1–8. doi:10.1016/j.eplepsyres.2013.08.016.

LoPinto-Khoury C, Mintzer S. Antiepileptic drugs and markers of vascular risk. Current Treatment Options in Neurology. 2010;12:300–8. doi:10.1007/s11940-010-0080-y.

Hamed SA, Fida NM, Hamed EA. States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. European Journal of Paediatric Neurology. 2009;13(3):261–8. doi:10.1016/j.ejpn.2008.05.005.

Liang Y, Chen X, Osborne M et al. Topiramate ameliorates hyperglycaemia and improves glucose-stimulated insulin release in ZDF rats and db/db mice. Diabetes Obesity and Metabolism. 2005 Aug 1;7:360–9. doi:10.1111/j.1463-1326.2004.00403.x.

Ani M, Moshtaghie SA, Akbarzadeh S. Changes in Biochemical Parameters Related to Lipid Metabolism Following Lithium Treatment in Rat. Iranian Biomedical Journal. 2005 Jan 15;9:27–32.

Verrotti A, Manco R, Agostinelli S et al. The metabolic syndrome in overweight epileptic patients treated with valproic acid. Epilepsia. 2010;51(2):268–73. doi:10.1111/j.1528-1167.2009.02206.x.

Chuang Y, Chuang H, Lin T et al. Effects of long‐term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis. Epilepsia. 2012;53(1):120–8. doi:10.1111/j.1528-1167.2011.03316.x.

Abaci A, Saygi M, Yis U et al. Metabolic alterations during valproic acid treatment: a prospective study. Pediatric Neurology. 2009;41(6):435–9. doi:10.1016/j.pediatrneurol.2009.06.003.

Mintzer S, Skidmore CT, Abidin CJ et al. Effects of antiepileptic drugs on lipids, homocysteine, and C‐reactive protein. Annals of Neurology. 2009;65(4):448–56. doi:10.1002/ana.21615.

Franzoni E, Verrotti A, Sarajlija J et al. Topiramate: effects on serum lipids and lipoproteins levels in children. European Journal of Neurology. 2007 Dec 1;14(12):1334–7. doi:10.1111/j.1468-1331.2007.01973.x

Isojärvi JIT, Rättyä J, Myllylä V V et al. Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy. Annals of Neurology. 1998 Apr 1;43(4):446–51. doi:10.1002/ana.410430406

Gramaglia E, Ramella Gigliardi V, Olivetti I et al. Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects. The Journal of Endocrinological Investigation. 2014;37:203–6. doi:10.1007/s40618-013-0016-y.

Srinivasan V, Ohta Y, Espino J et al. Metabolic syndrome, its pathophysiology and the role of melatonin. Recent Patents on Endocrine Metabolic and Immune Drug Discovery. 2013;7(1):11–25. doi:10.2174/187221413804660953

Borba C, Fan X, Copeland P et al. Placebo-Controlled Pilot Study of Ramelteon for Adiposity and Lipids in Patients With Schizophrenia. Journal of Clinical Psychopharmacology. 2011 Aug 24;31:653–8. doi:10.1097/JCP.0b013e31822bb573

Karaiskos D, Tzavellas E, Ilias I et al. Agomelatine and sertraline for the treatment of depression in type 2 diabetes mellitus. International Journal of Clinical Practice. 2013 Mar 1;67:257–60. doi:10.1111/ijcp.12112.

Charach G, Kaysar N, Rabinovich A, Jill Dr NM. Methylphenidate and dyslipidemia. Current Directions in ADHD and Its Treatment. 2012;185–92.