Pharmacological, Anticancer And Biological Studies On Algae

Aboelfetoh E., (2017), Eco-Friendly Synthesis of Silver Nanoparticles Using Green Algae (Caulerpa serrulata): Reaction Optimization, Catalytic and Antibacterial Activities, Environ.Monit.Assess, 189: 349. https://doi.org/10.1007/s10661-017-6033-0.

Ajarem S.J., (2021), Benign Synthesis of Cobalt Oxide Nanoparticles Containing Red Algae Extract: Antioxidant, Antimicrobial, Anticancer, and Anticoagulant Activity, Journal of Cluster Science.

Alboofethyleh M., (2019), Effect of Different non-Conventional Extraction Methods on The Anti- bacterial and Antiviral Activity of Fucoidans Extracted from Nizamuddinia zanardinii, International Journal of Biological Macromolecules, 124:131–137. https://doi.org/10.1016/j.ijbio- mac.2018.11.201.

Al-Enazi N.M., (2018), Antimicrobial, Antioxidant and Anticancer Activities of Laurencia catari- nensis, Laurencia majuscula and Padina pavonica Extracts, Saudi Pharmaceutical Journal, 26: 44–52. https://doi.org/10.1016/j.jsps.2017.11.001.

Alghazeer R., (2017), In Vitro Antibacterial Activity of Flavonoid Extracts of Two Selected Libyan Algae against Multi-Drug Resistant Bacteria Isolated from Food Products, Journal of Biosciences and Medicines, 5:26-48. http://www.scirp.org/journal/jbm.

Ananthi S., (2010), In Vitro Antioxidant and in Vivo Anti-Inflammatory Potential of Crude Polysac- charide from Turbinaria ornata (Marine Brown Alga), Food and Chemical Toxicology, 48:187– 192. http://dx.doi.org/10.1016/j.fct.2009.09.036.

Arya A., (2018), Biogenic Synthesis of Copper and Silver Nanoparticles Using Green Alga Botryococcus braunii and Its Antimicrobial Activity, Bioinorganic Chemistry and Applications, 8:9. https://doi. org/10.1155/2018/7879403.

Balaji M., (2017), Anticancer, Antioxidant Activity and GC-MS Analysis of Selected Micro Algal Mem- bers of Chlorophyceae, International Journal of Pharmaceutical Sciences and Research, 8(8): 3302-3314. https://doi.org/10.13040/IJPSR.0975-8232.8(8).3302-14.

Bergé J.P., (2002), In Vitro Anti-inflammatory and Anti-proliferative Activity of Sulfolipids from the Red Alga Porphyridium cruentum, J. Agric. Food Chem., 50: 6227-6232. https://doi.org/10.1021/ jf020290y.

Bitencourt F., (2008), Antinociceptive and Anti-Inflammatory Effects of A Mucin-Binding Agglutinin Isolated from The Red Marine Alga Hypnea cervicornis, Naunyn-Schmiedeberg’s Arch Pharma- col 377:139–148. https://doi.org/10.1007/s00210-008-0262-2.

Bourguiba I., (2017), Antioxidant Effect of The Marine Green Alga Ulva rigida Ethanolic Precipitate in Yeast Cells and Zebrafish Embryos, South African Journal of Botany, 113: 253–260. http://dx.doi. org/10.1016/j.sajb.2017.09.001.

Bάcsi I., (2016), Effects of Non-steroidal Anti-Inflammatory Drugs on Cyanobacteria and Algae in Laboratory Strains and in Natural Algal Assemblages, Environmental Pollution, 212:508-518. http://dx.doi.org/10.1016/j.envpol.2016.02.031.

Carneiro J., (2014), Peripheral Antinociception and Anti-Inflammatory Effects of Sulphated Poly- saccharides from the Alga Caulerpa mexicana, Basic & Clinical Pharmacology & Toxicology, 115:335–342. https://doi.org/10.1111/bcpt.12234.

Cavalcante-Silva L., (2012), Antinociceptive and Anti-Inflammatory Activities of Crude Metha- nolic Extract of Red Alga Bryothamnion triquetrum, Mar. Drugs., 10: 1977-1992. https://doi. org/10.3390/md10091977.

Challouf R., (2012), Antibacterial, Antioxidant and Cytotoxic Activities of Extracts from The Ther- mophilic, African Journal of Biotechnology, 11 (82):14844-14849. https://doi.org/10.5897/ AJB12.1118.

Dell’Anno M., (2020), In Vitro Evaluation of Antimicrobial and Antioxidant Activities of Algal Extracts, Italian Journal of Animal Science, 19(1): 103–113. https://doi.org/10.1080/182805 1X.2019.1703563.

Dimou M., (2016), Disulfides with Anti-inflammatory Activity from the Brown Alga Dictyopteris membranacea, J. Nat. Prod., 79:584−589. https://doi.org/10.1021/acs.jnatprod.5b01031.

El-Shafay S., (2021), Antioxidant, Antidiabetic, Anti-Inflammatory and Anticancer Potential of Some Seaweed Extracts, Food Sci. Technol. https://doi.org/10.1590/fst.20521.

El – Shoubaky G., (2016), Isolation and Identification of a Flavone Apigenin from Marine Red Alga Acanthophora spicifera with Antinociceptive and Anti-Inflammatory Activities, Journal of Experi- mental Neuroscience, 10:21-29. https://doi.org/10.4137/JEn.s25096.

Eom S., (2015), In Vitro Antiviral Activity of Dieckol and Phlorofucofuroeckol-A Isolated from Edib- le Brown Alga Eisenia bicyclis Against Murine Norovirus, Algae, 30(3): 241-246. http://dx.doi. org/10.4490/algae.2015.30.3.241.

Fatima R., (2019), Biosynthesis of Silver Nanoparticles Using Red Algae Portieria hornemannii and its Antibacterial Activity Against Fish Pathogens, Journal Pre-Proof, S0882-4010(18)31582-1. htt- ps://doi.org/10.1016/j.micpath.2019.103780.

Gong Y., (2021), Structural Characteristics and Anti-Inflammatory Activity of UV/H2O2-Treated Algal Sulfated Polysaccharide from Gracilaria lemaneiformis, Food and Chemical Toxicology, 152:112157. https://doi.org/10.1016/j.fct.2021.112157.

Gomaa H., (2016), Antiviral Activity of Sulfated Polysaccharides Carrageenan from Some Marine Seaweeds, International Journal of Current Pharmaceutical Review and Research, 7(1); 34-42.

Gopu M., (2021), Green Biomimetic Silver Nanoparticles Utilizing The Red Algae Amphiroa rigida and Its Potent Antibacterial, Cytotoxicity and Larvicidal Efficiency, Bioprocess and Biosystems Engineering, 44:217–223. https://doi.org/10.1007/s00449-020-02426-1.

Grünewald N., (2009), Optimized and Standardized Isolation and Structural Characterization of Anti-inflammatory Sulfated Polysaccharides from the Red Alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae), Biomacromolecules, 10:2998–3008. https://doi. org/10.1021/bm900501g.

Gu H., (2018), Ultrasound-Assisted Biosynthesis of CuO-NPs Using Brown Alga Cystoseira trinodis: Characterization, Photocatalytic AOP, DPPH Scavenging and Antibacterial Investigations, Ultra- sonics – Sonochemistry, 41: 109–119. https://doi.org/10.1016/j.ultsonch.2017.09.

Hamouda R.A., (2019), Comparative Study Between Two Red Algae for Biosynthesis Silver Nanopar- ticles Capping by SDS: Insights of Characterization and Antibacterial Activity, Microbial Pathoge- nesis, 129 :224–232. https://doi.org/10.1016/j.micpath.2019.02.016.

Ham Y.M., (2015), Anti-Inflammatory Effects of Isoketocharbroıc Acıd from Brown Alga, Sargassum mıcracanthum, Excli Journal, 14:1116-1121. http://dx.doi.org/10.17179/excli2015-555.

Han Y., (2015), Anti-Diabetic and Anti-Inflammatory Potentıal of The Edible Brown Alga Hizikia fusiformis, Journal of Food Biochemistry, 39:417–428. https://doi.org/10.1111/jfbc.12138.

Hardouin K., (2016), Enzyme-Assisted Extraction (EAE) for The Production of Antiviral and Antioxi- dant Extracts from The Green Seaweed Ulva armoricana (Ulvales, Ulvophyceae), Algal Research, 16: 233–239. http://dx.doi.org/10.1016/j.algal.2016.03.013.

aq S.H., (2019), Antioxidant, Anticancer Activity and Phytochemical Analysis of Green Algae, Chae- tomorpha Collected from the Arabian Gulf, Scientific Reports, 9:18906. https://doi.org/10.1038/ s41598-019-55309-1.

Hwang H., (2020), Characterization of a Novel Mannose-Binding Lectin with Antiviral Activities from Red Alga, Grateloupia chiangii, Biomolecules, 10, 333.

Ibrahim E.A., (2016), Marine Algal Sterol Hydrocarbon with Anti-Inflammatory, Anticancer and An- ti-Oxidant Properties, Int. J. Pharm. Bio. Sci., 7(3): 392 – 398.

Islam M.N., (2013), Anti-Inflammatory Activity of Edible Brown Alga Saccharina japonica and Its Constituents Pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells, Food and Chemical Toxicology, 55:541–548. http://dx.doi.org/10.1016/j.fct.2013.01.054.

Ismail A., (2018), Antimicrobial Fatty Acids from Green Alga Ulva rigida (Chlorophyta), BioMed Research International, 12. https://doi.org/10.1155/2018/3069595.

Kaçmaz M.S., (2016), Van Havzasında Bulunan Bazı Su Yosunlarının (Algae) Besin Madde İçeriğinin Araştırılması, Yüzüncüyıl Üniversitesi, Fen Bilimleri Enstitüsü, Zootekni Ana Bilim Dalı, Yük- sek Lisans Tezi.

Karpiński T., (2019), Fucoxanthin—An Antibacterial Carotenoid, Antioxidants, 8: 239. https://doi. org/10.3390/antiox8080239.

Kim H., (2018), In Vitro Antibacterial Activity of Phlorotannins from Edible Brown Algae, Eisenia bicyclis Against Streptomycin-Resistant Listeria monocytogenes, Indian.J.Microbiol., 58(1):105– 108. https://doi.org/10.1007/s12088-017-0693-x.

Komatsu T., (2013), Antiviral Activity of Acidic Polysaccharides from Coccomyxa gloeobotrydiformi, A Green Alga, Against An in Vitro Human Influenza A Virus Infection, Immunopharmacology and Immunotoxicology, 35(1): 1–7. https://doi.org/10.3109/08923973.2012.710636.

Lajili S., (2016), In Vitro Immunomodulatory Activity and In Vivo Anti-Inflammatory and Analgesic Potential with Gastroprotective Effect of The Mediterranean Red Alga Laurencia obtusa, Pharma- ceutical Biology, 54(11): 2486–2495. https://doi.org/10.3109/13880209.2016.1160937.

Lauritano C., (2016), Bioactivity Screening of Microalgae for Antioxidant, Anti-Inflammatory, Anti- cancer, Anti-Diabetes and Antibacterial Activities, Frontiersin Marine Science, 3,68. https://doi. org/10.3389/fmars.2016.00068.

Lee J., (2013), Marine Algal Natural Products with Anti-Oxidative, Anti-Inflammatory and Anti-Can- cer Properties, Cancer Cell International, 13:1-55. https://doi.org/10.1186/1475-2867-13-55.

Li K., (2021), Naturally Occurring Ureidobromophenols with Potent Antioxidant Activities from The Marine Red Alga Rhodomela confervoides, Algal Research, 56: 102312. https://doi.org/10.1016/j. algal.2021.102312.

Maggio A., (2022), Antibacterial Activity and HPLC Analysis of Extracts from Mediterranean Brown Algae, Plant Biosystems – An International Journal Dealing with All Aspects of Plant Bio- logy,156(1): 43-50. https://doi.org/10.1080/11263504.2020.1829737.

Malyarenko O.S., (2021), Combined Anticancer Effect of Sulfated Laminaran from the Brown Alga Alaria angusta and Polyhydroxysteroid Glycosides from the Starfish Protoreaster lincki on 3D Colorectal Carcinoma HCT 116 Cell Line, Mar. Drugs., 19, 540. https://doi.org/10.3390/ md19100540.

Manilal A., (2011), Biological Activity of The Red Alga Laurencia brandenii, Acta Bot. Croat., 70(1): 81-90. https://doi.org/10.2478/v10184-010-0001-x.

Mashjoor S., (2016), Cytotoxicity and Antimicrobial Activity of Marine Macro Algae (Dictyotaceae and Ulvaceae) from The Persian Gulf, Cytotechnology, 68:1717–1726. https://doi.org/10.1007/ s10616-015-9921-6.

Mohamed S., (2015), Characterization of Sulphated Polysaccharide with Antiviral Activity from Ma- rine Brown Alga Cystoseira myrica Collected from Jazan Coasts, KSA, International Journal of PharmTech Research, 8 (10): 198-203.

Murray M., (2018), Do Marine Algal Polyphenols Have Antidiabetic, Antihyperlipidemic or Anti-inf- lammatory Effects in Humans? A systematic review, Critical Reviews in Food Science and Nutri- tion, 58(12): 2039–2054. https://doi.org/10.1080/10408398.2017.1301876.

Nishida Y., (2020), Efficient Extraction and Antioxidant Capacity of Mycosporine-Like Amino Acids from Red Alga Dulse Palmaria palmata in Japan, Mar. Drugs., 18: 502. https://doi.org/10.3390/ md18100502.

Özkaya N., (2012), Bakır(III) İyonlarının Akdeniz’de Üreyen Kahverengi Alglerden Padina pavonia ve Dictyota dichotoma’ya Biyosorpsiyonuna Çevresel Koşulların ve Alglerin Aljinat İçeriğinin Etkisi- nin Araştırılması, Mersin Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Mühendisliği Ana Bilim Dalı, Yüksek Lisans Tezi.

Pagarete A., (2021), Antiviral Potential of AlgalMetabolites—A Comprehensive Review, Mar. Drugs., 19, 94. https://doi.org/10.3390/md19020094.

Parthasarathy R., (2020), Molecular Profiling of Marine Endophytic Fungi from Green Algae: Assess- ment of Antibacterial and Anticancer Activities, Process Biochemistry. https://doi.org/10.1016/j. procbio.2020.05.012.

Paula de Castro J., (2018), Polysaccharides of Red Alga Gracilaria intermedia: Structure, Antioxidant Activity and Rheological Behavior, Polímeros, 28(2): 178-186. http://dx.doi.org/10.1590/0104- 1428.013116.

Pereira D.M., (2011), Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines, Mar. Drugs., 9: 852-862. https://doi. org/10.3390/md9050852.

Ponnan A., (2017), Antibacterial, Antioxidant and Anticancer Properties of Turbinaria conoides (J. Agardh) Kuetz, Clinical Phytoscience, 3:5. https://doi.org/10.1186/s40816-017-0042-y.

Rafiquzzaman S.M., (2016), Phytochemical Composition and Antioxidant Activity of Edible Red Alga Hypnea muscıformıs from Bangladesh, Phytochemical and Antioxidant Activity. https://doi. org/10.1111/jfpp.12688.

Rafiquzzaman S.M., (2015), Anti-Alzheimers and Anti-Inflammatory Activities of A Glycoprotein Purified from The Edible Brown Alga Undaria pinnatifida, Food Research International, 77:118– 124. http://dx.doi.org/10.1016/j.foodres.2015.08.021.

Rajivgandhi G., (2016), Molecular Characterization and Antibacterial Effect of Endophytic Actinom- ycetes Nocardiopsis sp. GRG1 (KT235640) from Brown Algae Against MDR Strains of Uropat- hogens, Bioactive Materials, 1: 140-150. http://dx.doi.org/10.1016/j.bioactmat.2016.11.002.

Reyes C., (2016), Cystoseira usneoides: A Brown Alga Rich in Antioxidant and Antiinflammatory Me- roditerpenoids, J. Nat. Prod., 79:395−405. https://doi.org/10.1021/acs.jnatprod.5b01067.

Salhi G., (2018), Antitumoral and Anti-Inflammatory Activities of The Red Alga Sphaerococcus Co- ronopifolius, European Journal of Integrative Medicine, 18:66–74. https://doi.org/10.1016/j.eu- jim.2018.02.001.

Santhakumaran P., (2020), Nutraceutical Applications of Twenty-five Species of Rapid-Growing Gre- enmicroalgae As Indicated by Their Antibacterial, Antioxidant and Mineral Content, Algal Rese- arch, 47: 101878. https://doi.org/10.1016/j.algal.2020.101878.

Sato N., (2018), Antioxidant Activity of Proteins Extracted from Red Alga Dulse Harvested in Japan, J.Food.Biochem., 12709. https://doi.org/10.1111/jfbc.12709.

Selvaraj P., (2020), Antibacterial Potentials of Methanolic Extract and Silver Nanoparticles from Ma- rine Algae, Biocatalysis and Agricultural Biotechnology, 28: 101719. https://doi.org/10.1016/j. bcab.2020.101719.

Shanmugapriya R., (2015), Anticancer Effect of The Marine Micro Alga, Skeletonema costatum (Gre- ville) Cleve on Human Cervical Cancer Cell Line, Asian Journal of Pharmaceutical Science & Technology, 5(2):98-101.

Silva M., (2010), Antinociceptive and Anti-Inflammatory Activities of Lectin from Marine Red Alga Pterocladiella capillacea, Biol. Pharm. Bull., 33(5): 30—835. http://dx.doi.org/10.1016/j.in- timp.2010.06.014.

Souza R.B., (2018), In Vitro Activities of Kappa-Carrageenan Isolated from Red Marine Alga Hypnea musciformis: Antimicrobial, Anticancer and Neuroprotective Potential, International Journal of Biological Macromolecules, 112: 1248–1256. https://doi.org/10.1016/j.ijbiomac.2018.02.029.

Sousa A., (2013), A Report of A Galactan from Marine Alga Gelidium crinale with In Vivo Antiinflam- matory and Antinociceptive Effects, Fundamental & Clinical Pharmacology, 27: 173–180. https:// doi.org/10.1111/j.1472-8206.2011.01001.x.

Usoltseva R.V., (2017), Polysaccharides from Brown Algae Sargassum duplicatum: The Structure and Anticancer Activity In Vitro, Carbohydrate Polymers, 175:547–556.

Vanderlei E.S.O., (2010), Antinociceptive and Anti-Inflammatory Activities of Lectin from The Marine Green Alga Caulerpa cupressoides, International Immunopharmacology, 10:1113–1118. http:// dx.doi.org/10.1016/j.intimp.2010.06.014.

Vimala T., (2017), In vitro antimicrobial activity of solvent extracts of marine brown alga, Hydroclath- rus clathratus (C. Agardh) M. Howe from Gulf of Mannar, Journal of Applied Pharmaceutical Science, 7 (04): 157-162. https://doi.org/10.7324/JAPS.2017.70423.

Vishwakarma J., (2019), Evaluating The Antibacterial and Antibiofilm Potential of Sulphated Polysac- charides Extracted from Green Algae Chlamydomonas reinhardtii, Journal of Applied Microbio- logy. 127: 1004-1017.

Yang E., (2013), Anti-Inflammatory Effects of Apo-9′-fucoxanthinone from The Brown Alga, Sargas- sum muticum, DARU Journal of Pharmaceutical Sciences, 2:1-62. https://doi.org/10.1186/2008- 2231-21-62.

Zbakh H., (2020), Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflam- matory and Lung Anticancer Agents, Mar. Drugs., 18-207. https://doi.org/10.3390/md18040207. Zhang X., (2019), Preparation and Identification of Antioxidant Peptides from Protein Hydrolysate of Marine Alga Gracilariopsis lemaneiformis, Journal of Applied Phycology, 31:2585–2596. https://

doi.org/10.1007/s10811-019-1746-9.

Wali A., (2020), LC-MS Phytochemical Screening, In Vitro Antioxidant, Antimicrobial and Anti- cancer Activity of Microalgae Nannochloropsis oculata Extract, Separations, 7: 54. https://doi. org/10.3390/separations7040054.

Wang S., (2018), Antiviral Activity Against Enterovirus 71 of Sulfated Rhamnan Isolated from The Gre- en Alga Monostroma latissimum, Carbohydrate Polymers, 200: 43–53. https://doi.org/10.1016/j. carbpol.2018.07.067.

Wu G.J., (2016), Anti-Inflammatory Activity of A Sulfated Polysaccharide from The Brown Alga Sargassum cristaefolium, Food Hydrocolloids, 53:16-23. http://dx.doi.org/10.1016/j.foo- dhyd.2015.01.019