Obezite ve Anestezi
Synopsis
Obesity, defined by the World Health Organization as an abnormal or excessive accumulation of fat that poses health risks, presents a high-risk scenario that directly complicates anesthetic management through the pathophysiological changes it causes across bodily systems. Classified by Body Mass Index (BMI) and waist circumference measurements, obesity leads to significant dysfunction in the cardiovascular, respiratory, endocrine, urogenital, and gastrointestinal systems. Anatomical factors such as fat accumulation in the airway, a short neck, and restricted mobility increase the incidence of difficult mask ventilation and tracheal intubation. Furthermore, decreased functional residual capacity and lung compliance cause rapid oxygen desaturation during apnea periods. Due to changes in drug distribution volume and clearance, dosages of anesthetic agents and neuromuscular blockers must be meticulously calculated based on Ideal Body Weight (IBW) or Lean Body Weight (LBW). Preoperative evaluation requires detailed screening for comorbidities, sleep apnea, and thromboembolism risk, while intraoperative management should utilize the ramp position, appropriate PEEP, and lung-protective ventilation strategies. Finally, postoperative care aims to prevent potential atelectasis, hypoxia, and cardiac complications through multimodal analgesia, early mobilization, proper positioning, and respiratory support.
References
WHO.World Health Organization.2016.ProMED-mail website. Available at: www.who.int/mediacentre/factsheets/fs311/en/. Accessed 19 March 2020.
http://www.who.int/mediacentre/factsheets/fs311/en/, erişim tarihi: 04.11. 2013
TürkiyeEndokrinolojiveMetabolizmaDerneği. Obezite Tanı ve Tedavi Kılavuzu 2019 [Available from: http://temd.org.tr/admin/uploads/tbl_kilavuz/20190506163904- 2019tbl_kilavuz5ccdcb9e5d.pdf.
Hill JO, Wyatt H. Outpatient management of obesity: a primary care perspective. Obes Res. 2002;10 Suppl 2:124s-30s.
Jensen MD, Ryan DH, Apovian CM. AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation, 2014; 129, 102-138.
Prevention and management of the global epidemic of obesity. Report of the WHO Consultation on Obesity (Geneva, June, 3–5, 1997). Geneva: WHO.
Schumann R. Anaesthesia for bariatric surgery. Best Pract Res Clin Anaesthesiol, 2011; 25, 83-93.
Glance LG, Dick AW, Mukamel DB. Perioperative outcomes among patients with the modified metabolic syndrome who are undergoing noncardiac surgery. Anesthesiology, 2010; 113, 859-72.
Juvin P, Lavaut E, Dupont H. Difficult tracheal intubation is more common in obese than in lean patients. Anesth Analg, 2003; 97, 595-600.
Ortiz VE, Kwo J. Obesity: physiologic changes and implications for preoperative management. BMC Anesthesiol, 2015; 15, 97.
Kenchaiah S, Evans JC, Levy D. Obesity and the risk of heart failure. N Engl J Med, 2002; 347(5), 305–313.
Shihab HM, Meoni LA, Chu AY. Body mass index and risk of incident hypertension over the life course: the Johns Hopkins Precursors Study. Circulation, 2012; 126(25), 2983–2989.
Magnani JW, Hylek EM, Apovian CM. Obesity begets atrial fibrillation: a contemporary summary. Circulation, 2013; 128(4), 401–405.
Steier J, Lunt A, Hart N. Observational study of the effect of obesity on lung volumes. Thorax, 2014; 69(8), 752–759.
Hodgson LE, Murphy PB, Hart N. Respiratory management of the obese patient undergoing surgery. J Thorac Dis, 2015; 7(5), 943–952.
Pankow W, Podszus T, Gutheil T. Expiratory flow limitation and intrinsic positive end-expiratory pressure in obesity. J Appl Physiol, 1998; 85(4), 1236–1243.
Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a metaanalysis of prospective epidemiologic studies. Am J Respir Crit Care Med, 2007; 175(7), 661–666.
Nightingale CE, Margarson MP, Shearer E. Peri-operative management of the obese surgical patient 2015: Association of Anaesthetists of Great Britain and Ireland Society for Obesity and Bariatric Anaesthesia. Anaesthesia, 2015; 70(7), 859–876
Iftikhar IH, Roland J. Obesity Hypoventilation Syndrome. Clin Chest Med, 2018; 39, 427-436.
Mechanick JI, Youdim A, Jones DB. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity, 2013; 21(1), 1–27.
Junior GBS, Bentes ASN, Daher EF. Obesity and Kidney Disease. J BrasNefrol, 2017; 39(1), 65-69.
Considine RV, Sinha MK, Heiman ML. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. The New England journal of medicine, 1996; 334(5), 292-295.
Vrbikova J, Hainer V. Obesity and polycystic ovary syndrome. Obes Facts. 2009; 2, 26-35.
Tankurt E. (2010). Yağlı Karaciğer Hastalığı. Kalaycı C, Dabak R (Ed). Gastroenteroloji Hepatoloji Tanı ve Tedavi (219-224).
Tchernof A, Lamarche B, Prud’Homme D. The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care, 1996; 19, 629-637.
Çavuş B, Karaca Ç. Safra Taşı Hastalığı. İç hastalıkarı dergisi, 2013; 20, 151-160.
Willis S, Bordelon GJ, Rana MV. Perioperative pharmacologic considerations in obesity. Anesthesiol Clin, 2017; 35(2), 247–257.
Sarandan M, Guragata-Balasa C, Papurica M. Anesthesia in laparacopik bariatric surgery (gastric sleeve): preliminary experience. Timisoara Medical Journal, 2011; 61, 26-31.
Guh DP, Zhang W, Bansback N. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health, 2009; 25, 88.
Al-Mobeireek AF, Al-Kassimi FA, Al-Majed SA. Clinical profile of sleep apnea syn¬drome. A study at a university hospital. Saudi Med. , 2000; 21, 180-183.
Ronald D. Miller. 2005. Miller’s anesthesia. Anesthetic implications of concurrent diseases. Chapter 27, Michael F. Roizen,Lee A. Fleisher, eds. Elseiver. Philadelphia, pp. 1028-1034
Lotia S, Bellamy MC. Anaesthesia and morbid obesity. Critical Care Pain, 2008; 8: 151-56.
Domi R, Laho H. Anesthetic challenges in the obese patient. J Anesth, 2012; 26: 758-765.
Jayaraman L, Sinha A, Punhani D. A comparative study to evaluate the effect of intranasal dexmedetomidine versus oral alprazolam as a premedication agent in morbidly obese patients undergoing bariatric surgery. J Anaesthesiol Clin Pharmacol, 2013: 29 (2), 179.
Perilli V, Sollazzi L, Bozza P. The effects of the reverseTrendelenburg position on respiratory mechanics and blood gases in morbidly obese patients during bariatric surgery. Anesth Analg, 2000; 91,1520-1525.
Wadhwa A, Singh PM, Sinha AC. Airway management in patients with morbid obesity. Int Anesthesiol Clin, 2013; 51, 26-40.
Baturay F, Topuz C, Ay A. Obezite ve Anestezi. Okmeydanı Tıp Dergisi, 2014; 30(ES 1), 29-33.
La Colla L, Albertin A, La Colla G. Faster Wash-out and Recovery for Desflurane vs Sevoflurane in Morbidly Obese Patients when no Premedication is Used. Br J Anaesth, 2007; 99(3), 353-358.
Pelosi P, Gregoretti C. Perioperative management of obese patients. Best Pract Res Clin Anaesthesiol, 2010; 24, 2112-2125.
Cadi P, Guenoun T, Journois D. Pressure-controlled ventilation improves oxygenation during laparoscopic obesity surgery compared with volume-controlled ventilation. Br J Anaesth, 2008; 100, 709-716.
Van Lancker P, Dillemans B, Bogaert T, Mulier JP, De Kock M, Haspeslagh M. Ideal versus corrected body weight for dosage of sugammadex in morbidly obese patients. Anaesthesia, 2011; 66, 721-725.
Gross JB, Bachenberg KL, Benumof JL. Practice guidelines for the perioperative management of patients with obstructive sleep apnea: A report by the American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea. Anesthesiology, 2006; 104, 1081-1093.
Ingrande J, Brodsky JB, Lemmens HJM. Regional anesthesia and obesity. Curr Opin Anaesthesiol, 2009; 22, 683-686
Taivainen T, Tuominen M, Rosenberg PH. Influence of obesity on the spread of spinal analgesia after injection of plain 0.5 % bupivacaine at the L3-4 and the L4-5 interspace. Br J Anesth, 1990; 64, 542-546
Nielsen KC, Guller U, Steele SM. Influence of obesity on surgical regional anesthesia in the ambulatory setting: an analysis of 9,038 blocks. Anesthesiology, 2005; 102(1), 181–7.
McManus LM, Bloodworth RC, Prihoda TJ. Agonist-dependent failure of neutrophil function in dia¬betes correlates with extent of hyperglycemia. J. Leukocyte. Biol, 2001; 70, 395-404.
Pryor KO, Fahey III TJ. Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial. JAMA, 2004; 291, 79-87.
Gander S, Frascarolo P, Suter M. Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients. Anesth. Analg, 2005; 100, 580-584.
Lewandowski K, Lewandowski M. Intensive care in the obese. Best Pract Res Clin Anaesthesiol, 2011; 25, 95-108.
Bamgbade OA, Rutter TW, Nafiu OO. Postoperative complications in obese and nonobese patients. World Journal of Sur¬gery, 2007; 31, 556-560.