Transseksüel Hastalarda Anestezi Yönetimi
Özet
Transseksüel bireylerde anestezi yönetimi; preoperatif, intraoperatif ve postoperatif dönemlerde hasta güvenliğini ve konforunu sağlamak adına ayrıntılı, hassas ve özgün bir değerlendirme gerektirmektedir. Cinsiyet uyum ameliyatları ve diğer tıbbi müdahalelerin sayısının artmasıyla birlikte, perioperatif süreçte kullanılan Cross-Sex Hormone Therapy (CSHT) tedavileri, ilaç etkileşimleri ve olası klinik riskler dikkatle ele alınmalıdır. Preoperatif aşamada, hastanın kendini güvende hissettiği kültürel olarak uygun bir ortam sağlanmalı, hastanın tercih ettiği ad ve cinsiyet kimliğine saygı gösterilmelidir. Hormon tedavisinin laboratuvar testleri üzerindeki biyokimyasal etkileri, artan venöz tromboembolizm (VTE) ve kardiyovasküler hastalık riskleri dikkate alınarak ameliyat öncesi hormonal tedavinin kesilme kararı cerrah ve endokrinolog iş birliğiyle belirlenmelidir. Ayrıca, vokal kord ve yüz cerrahilerine bağlı trakeal darlık gelişebileceğinden zor havayolu hazırlığı yapılmalı; HIV prevalansı, sigara kullanımı ve ruhsatsız dolgu/silikon uygulamalarının olası ciddi sistemik komplikasyonları detaylıca sorgulanmalıdır. İntraoperatif dönemde, anestezik ilaç dozlamalarında kullanılan ideal vücut ağırlığı hesaplamaları ve TCI algoritmaları gözden geçirilmeli, anestezi derinliğinin izleminde BIS gibi yöntemlerden yararlanılmalıdır. Postoperatif süreçte ise depresyon, anksiyete ve opioid bağımlılığı riski göz önünde bulundurularak ağrı yönetimi titizlikle yürütülmeli, östrojen kullanımına bağlı artan bulantı-kusma insidansı ile hastanın mahremiyet ihtiyacına özen gösterilmelidir.
Referanslar
Flores AR, Herman JL, Gates GJ, et al. How manyadultsidentify as transgenderin the United States? Los Angeles (CA): The Williams Institute; 2016
Spizzirri G, Eufrásio R, Lima MCP, et al. Proportion of people identified as transgender and non-binary gender in Brazil. Sci Rep. 2021 Jan 26;11(1):2240. doi: 10.1038/s41598-021-81411-4. PMID: 33500432; PMCID: PMC7838397.
Tollinche LE, Van Rooyen C, Afonso A, et al. Considerations for Transgender Patients Perioperatively. Anesthesiol Clin. 2020 Jun;38(2):311-326. doi: 10.1016/j.anclin.2020.01.009. PMID: 32336386; PMCID: PMC7197403.
Grant JM, Motter LA, Tanis J, et al. Injustice at every turn: A report of the nationaltransgender discrimination survey. Washington, DC: National Center for Transgender Equality (NCTE) and National LGBTQ Task Force; 2011.
Deutsch MB, Buchholz D. Electronic health records and transgender patients--practical recommendations for the collection of gender identity data. J Gen Intern Med. 2015 Jun;30(6):843-7. doi: 10.1007/s11606-014-3148-7. Epub 2015 Jan 6. PMID: 25560316; PMCID: PMC4441683.
Cheng YJ, Liu ZH, Yao FJ, et al. Current and former smoking and risk for venous thromboembolism: a systematic review and meta-analysis. PLoS Med. 2013;10(9):e1001515. doi: 10.1371/journal.pmed.1001515. Epub 2013 Sep 17. PMID: 24068896; PMCID: PMC3775725.
Chan W, Drummond A, Kelly M. Deep vein thrombosis in a transgender woman. CMAJ. 2017 Apr 3;189(13):E502-E504. doi: 10.1503/cmaj.160408. PMID: 28385895; PMCID: PMC5378510.
Hage JJ, Kanhai RC, Oen AL, et al. The devastating outcome of massive subcutaneous injection of highly viscous fluids in male-to-female transsexuals. Plast Reconstr Surg. 2001 Mar;107(3):734-41. doi: 10.1097/00006534-200103000-00013. PMID: 11304599.
Visnyei K, Samuel M, Heacock L, et al. Hypercalcemia in a male-to-female transgender patient after body contouring injections: a case report. J Med Case Rep. 2014 Feb 26;8:71. doi: 10.1186/1752-1947-8-71. PMID: 24572248; PMCID: PMC3976093.
Wierckx K, Elaut E, Declercq E, et al. Prevalence of cardiovascular disease and cancer during cross-sex hormone therapy in a large cohort of trans persons: a case-control study. Eur J Endocrinol. 2013 Sep 13;169(4):471-8. doi: 10.1530/EJE-13-0493. PMID: 23904280.
Roberts TK, Kraft CS, French D, et al. Interpreting laboratory results in transgender patients on hormone therapy. Am J Med. 2014 Feb;127(2):159-62. doi: 10.1016/j.amjmed.2013.10.009. Epub 2013 Oct 19. PMID: 24332725.
Defreyne J, Vantomme B, Van Caenegem E, et al. Prospective evaluation of hematocrit in gender-affirming hormone treatment: results from European Network for the Investigation of Gender Incongruence. Andrology. 2018 May;6(3):446-454. doi: 10.1111/andr.12485. Epub 2018 Mar 30. PMID: 29602229.
SoRelle JA, Jiao R, Gao E, et al. Impact of Hormone Therapy on Laboratory Values in Transgender Patients. Clin Chem. 2019 Jan;65(1):170-179. doi: 10.1373/clinchem.2018.292730. Epub 2018 Dec 5. PMID: 30518663.
Hochberg Z, Pacak K, Chrousos GP. Endocrine withdrawal syndromes. Endocr Rev. 2003 Aug;24(4):523-38. doi: 10.1210/er.2001-0014. PMID: 12920153.
T'Sjoen G, Arcelus J, Gooren L, et al, Tangpricha V. Endocrinology of Transgender Medicine. Endocr Rev. 2019 Feb 1;40(1):97-117. doi: 10.1210/er.2018-00011. PMID: 30307546.
Lennie Y, Leareng K, Evered L. Perioperative considerations for transgender women undergoing routine surgery: a narrative review. Br J Anaesth. 2020 Jun;124(6):702-711. doi: 10.1016/j.bja.2020.01.024. Epub 2020 Mar 12. PMID: 32171545.
Alzahrani T, Nguyen T, Ryan A, et al. Cardiovascular Disease Risk Factors and Myocardial Infarction in the Transgender Population. Circ Cardiovasc Qual Outcomes. 2019 Apr;12(4):e005597. doi: 10.1161/CIRCOUTCOMES.119.005597. PMID: 30950651.
Irwig MS. Cardiovascular health in transgender people. Rev Endocr Metab Disord. 2018 Sep;19(3):243-251. doi: 10.1007/s11154-018-9454-3. PMID: 30073551.
Asscheman H, Giltay EJ, Megens JA, et al. A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones. Eur J Endocrinol. 2011 Apr;164(4):635-42. doi: 10.1530/EJE-10-1038. Epub 2011 Jan 25. PMID: 21266549.
Shah SB, Khanna P, Bhatt R, et al. Perioperative anaesthetic concerns in transgender patients: Indian perspective. Indian J Anaesth. 2019;63(2):84-91. doi:10.4103/ija.IJA_640_18
Tangpricha V, den Heijer M. Oestrogen and anti-androgen therapy for transgender women. Lancet Diabetes Endocrinol. 2017 Apr;5(4):291-300. doi: 10.1016/S2213-8587(16)30319-9. Epub 2016 Dec 2. PMID: 27916515; PMCID: PMC5366074.
Kozek-Langenecker S, Fenger-Eriksen C, Thienpont E, et al. European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly. Eur J Anaesthesiol. 2018 Feb;35(2):116-122. doi: 10.1097/EJA.0000000000000705. PMID: 28901992.
Cheung AS, Ooi O, Leemaqz S, et al. Sociodemographic and Clinical Characteristics of Transgender Adults in Australia. Transgend Health. 2018 Dec 26;3(1):229-238. doi: 10.1089/trgh.2018.0019. PMID: 30596151; PMCID: PMC6308273.
Rosa DF, Carvalho MVF, Pereira NR, et al. Nursing Care for the transgender population: genders from the perspective of professional practice. Rev Bras Enferm. 2019 Feb;72(suppl 1):299-306. English, Portuguese. doi: 10.1590/0034-7167-2017-0644. PMID: 30942376.
Oluwabukola A, Adesina O. Anaesthetic considerations for the hiv positive parturient. Ann Ib Postgrad Med. 2009 Jun;7(1):31-5. PMID: 25161460; PMCID: PMC4111002.
Bockting WO, Miner MH, SwinburneRomine RE, Hamilton A, Coleman E. Stigma, mentalhealth, andresilience in an online sample of the US transgenderpopulation. Am J PublicHealth. 2013; 103:943–951. [PubMed: 23488522]
Peck T, Wong A, Norman E. anaesthetic implications of psychoactive drugs. Continuing Education in Anaesthesia Critical Care & Pain, Volume 10, Issue 6, December 2010, Pages 177–181, https://doi.org/10.1093/bjaceaccp/mkq037
Arnold JD, Sarkodie EP, Coleman ME, et al. Incidence of Venous Thromboembolism in Transgender Women Receiving Oral Estradiol. J Sex Med. 2016 Nov;13(11):1773-1777. doi: 10.1016/j.jsxm.2016.09.001. Epub 2016 Sep 23. PMID: 27671969.
Pisklakov, Sergey MD; Carullo, Veronica MD. Care of the Transgender Patient: Postoperative Pain Management, Topics in Pain Management: June 2016 - Volume 31 - Issue 11 - p 1-8. doi: 10.1097/01.TPM.0000484122.79025.d6