Acil Serviste Warfarin (Coumadin) Toksisitesi Tanı ve Tedavi Yaklaşımı

Chapman SA, Irwin ED, Beal AL, et al. Prothrombin complex concentrate versus standard the- rapies for INR reversal in trauma patients receiving warfarin. Annals of Pharmacotherapy. 2011;45(7–8):869–875. doi:10.1345/aph.1P605

Sarode R, Milling TJ Jr, Refaai MA, et al. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomi- zed, plasma-controlled, phase IIIb study. Circulation. 2013;128(11):1234–1243. doi: 10.1111/ tme.12621

Wysowski DK, Nourjah P, Swartz L. Bleeding complications with warfarin use: a prevalent adver- se effect resulting in regulatory action. Archives of Internal Medicine. 2007;167(13):1414–1419. doi:10.1001/archinte.167.13.1414

Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th edition. Chest. 2012;141(2 Supp- l):e152S–e184S. doi:10.1378/chest.11-2295

Wang K, Zhang T, Rao J, et al. Drug–drug interactions induced by linderane based on mec- hanism-based inactivation of CYP2C9 and the molecular mechanisms. Bioorganic Chemistry. 2022;118:105478. doi:10.1016/j.bioorg.2021.105478

Lippi G, Favaloro EJ. Preanalytical issues in hemostasis and thrombosis testing. Methods in Mole- cular Biology. 2017;1646:29–42. doi:10.1007/978-1-4939-7196-1_2

Ansell J, Hirsh J, Hylek E, et al. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008;133(6 Suppl):160S–198S. doi:10.1378/chest.08-0670

Berling I, Mostafa A, Grice JE, et al. Warfarin poisoning with delayed rebound toxicity. Journal of Emergency Medicine. 2017;52(2):194–196. doi:10.1016/j.jemermed.2016.05.068

Witt DM, Clark NP, Kaatz S, et al. Guidance for the practical management of warfarin the- rapy in the treatment of venous thromboembolism. Journal of Thrombosis and Thrombolysis. 2016;41(1):187–205. doi:10.1007/s11239-015-1319-y

Tomaselli GF, Mahaffey KW, Cuker A, et al. 2020 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants. Journal of the American College of Cardiology. 2020;76(5):594–622. doi:10.1016/j.jacc.2020.04.053

Milling TJ Jr, Pollack CV Jr. A review of guidelines on anticoagulation reversal across diffe- rent clinical scenarios: Is there a general consensus? American Journal of Emergency Medicine. 2020;38(9):1890–1903. doi:10.1016/j.ajem.2020.05.086

Tran HA, Chunilal SD, Harper PL, et al. An update of consensus guidelines for warfarin reversal.

Medical Journal of Australia. 2013;198(4):198–199. doi:10.5694/mja12.10614

Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Annals of Internal Medicine. 2009;150(5):293–300. doi:10.7326/0003-4819-150-5-200903030-00005